1. Medzhitov，R.，Inflammation 2010：new adventures of an old flame.Cell，2010，140：771-776.

2. McFarland，H.F.and Martin，R.，Multiple sclerosis：a complicated picture of autoimmunity. Nat Immunol，2007，8：913-919.

3. Nathan，C. and Ding，A.，Nonresolving inflammation. Cell，2010，140：871-882.

4. Waldburger，J.M.and Firestein，G.S.，Garden of therapeutic delights：new targets in rheumatic diseases.Arthritis Res T-her，2009，11：206.

5. Gilroy，D.W.，Lawrence，T.，Perretti，M.and Rossi，A.G.，Inflammatory resolution：new opportunities for drug discovery. Nat Rev Drug Discov，2004，3：401-416.

6. Lawrence，T.，Willoughby，D.A.and Gilroy，D.W.，Anti-inflammatory lipid mediators and insights into the resolution of inflammation.Nat Rev Immunol，2002，2：787-795.

7. Baggiolini，M.and Loetscher，P.，Chemokines in inflammation and immunity.Immunol Today，2000，21：418-420.

8. Sallusto，F. and Baggiolini，M.，Chemokines and leukocyte traffic.Nat Immunol，2008，9：949-952.

9. Phillipson，M.，Heit，B.，Colarusso，P.，Liu，L.，Ballantyne，C. M.and Kubes，P.，Intraluminal crawling of neutrophils to emigration sites：a molecularly distinct process from adhesion in the recruitment cascade.J Exp Med，2006，203：2569-2575.

10. Cara，D.C.，Negrao-Correa，D.and Teixeira，M.M.，Mechanisms underlying eosinophil trafficking and their relevance in vivo.Histol Histopathol，2000，15：899-920.

11. Alessandri，A. L.，Duffin，R.，Leitch，A. E.，Lucas，C. D.，Sheldrake，T.A.，Dorward，D.A.，Hirani，N.，Pinho，V.，de Sousa，L. P.，Teixeira，M. M.，Lyons，J. F.，Haslett，C. and Rossi，A.G.，Induction of eosinophil apoptosis by the cyclindependent kinase inhibitor AT7519 promotes the resolution of eosinophil-dominant allergic inflammation. PLoS One，2011，6：e25683.

12. Vago，J.P.，Nogueira，C.R.，Tavares，L.P.，Soriani，F.M.，Lopes，F.，Russo，R. C.，Pinho，V.，Teixeira，M. M. and Sousa，L.P.，Annexin A1 modulates natural and glucocorticoid-induced resolution of inflammation by enhancing neutrophil apoptosis.J Leukoc Biol，2012，92：249-258.

13. Serhan，C.N.，Resolution phase of inflammation：novel endogenous anti-inflammatory and proresolving lipid mediators and pathways.Annu Rev Immunol 2007.25：101-137.

14. Spite，M.and Serhan，C.N.，Novel lipid mediators promote resolution of acute inflammation：impact of aspirin and statins.Circ Res 2010.107：1170-1184.

15. Levy，B.D.，Kohli，P.，Gotlinger，K.，Haworth，O.，Hong，S.，Kazani，S.，Israel，E.，Haley，K.J.and Serhan，C.N.，Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsiveness. J Immunol，2007，178：496-502.

16. Serhan，C.N.，Dalli，J.，Karamnov，S.，Choi，A.，Park，C.K.，Xu，Z.Z.，Ji，R.R.，Zhu，M.and Petasis，N.A.，Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain.FASEB J，2012，26：1755-1765.

17. Souza，D.G.，Fagundes，C.T.，Amaral，F.A.，Cisalpino，D.，Sousa，L.P.，Vieira，A.T.，Pinho，V.，Nicoli，J.R.，Vieira，L. Q.，Fierro，I.M.and Teixeira，M.M.，The required role of endogenously produced lipoxin A4 and annexin-1 for the production of IL-10 and inflammatory hyporesponsiveness in mice.J Immunol，2007，179：8533-8543.

18. Chiang，N.，Arita，M.and Serhan，C.N.，Anti-inflammatory circuitry：lipoxin，aspirin-triggered lipoxins and their receptor ALX.Prostaglandins Leukot Essent Fatty Acids，2005，73：163-177.

19. Maderna，P.and Godson，C.，Taking insult from injury：lipoxins and lipoxin receptor agonists and phagocytosis of apoptotic cells. Prostaglandins Leukot Essent Fatty Acids，2005，73：179-187.

20. Conte，F. P.，Menezes-de-Lima，O.，Jr.，Verri，W. A.，Jr.，Cunha，F. Q.，Penido，C. and Henriques，M. G.，Lipoxin A （4）attenuates zymosan-induced arthritis by modulating endothelin-1 and its effects.Br J Pharmacol，2010，161：911-924.

21. Gong，J.，Guo，S.，Li，H.B.，Yuan，S.Y.，Shang，Y.and Yao，S.L.，BML-111，a lipoxin receptor agonist，protects haemorrhagic shock-induced acute lung injury in rats.Resuscitation，2012，83：907-912.

22. El Kebir，D.，Jozsef，L.，Pan，W.，Wang，L.，Petasis，N.A.，Serhan，C.N.and Filep，J.G.，15-epi-lipoxin A4 inhibits myeloperoxidase signaling and enhances resolution of acute lung injury.Am J Respir Crit Care Med，2009，180：311-319.

23. Prieto，P.，Cuenca，J.，Traves，P. G.，Fernandez-Velasco，M.，Martin-Sanz，P.and Bosca，L.，Lipoxin A4 impairment of apoptotic signaling in macrophages：implication of the PI3K/Akt and the ERK/Nrf-2 defense pathways.Cell Death Differ，2010，17：1179-1188.

24. Serhan，C.N.and Petasis，N.A.，Resolvins and protectins in inflammation resolution.Chem Rev，2011，111：5922-5943.

25. El Kebir，D.，Gjorstrup，P.and Filep，J.G.，Resolvin E1 promotes phagocytosis-induced neutrophil apoptosis and accelerates resolution of pulmonary inflammation.Proc Natl Acad Sci U S A，2012，109：14983-14988.

26. Rogerio，A.P.，Haworth，O.，Croze，R.，Oh，S.F.，Uddin，M.，Carlo，T.，Pfeffer，M.A.，Priluck，R.，Serhan，C.N.and Levy，B.D.，Resolvin D1 and aspirin-triggered resolvin D1 promote resolution of allergic airways responses. J Immunol，2012，189：1983-1991.

27. Xu，Z.Z.，Zhang，L.，Liu，T.，Park，J.Y.，Berta，T.，Yang，R.，Serhan，C.N.and Ji，R.R.，Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions.Nat Med，2010，16：592-597，591p following 597.

28. Ohira，T.，Arita，M.，Omori，K.，Recchiuti，A.，Van Dyke，T. E.and Serhan，C.N.，Resolvin E1 receptor activation signals phosphorylation and phagocytosis.J Biol Chem，2010，285：3451-3461.

29. Dartt，D.A.，Hodges，R.R.，Li，D.，Shatos，M.A.，Lashkari，K.and Serhan，C.N.，Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammation.J Immunol，2011，186：4455-4466.

30. Duffield，J.S.，Hong，S.，Vaidya，V.S.，Lu，Y.，Fredman，G.，Serhan，C. N. and Bonventre，J. V.，Resolvin D series and protectin D1 mitigate acute kidney injury.J Immunol，2006，177：5902-5911.

31. Serhan，C.N.，Yang，R.，Martinod，K.，Kasuga，K.，Pillai，P. S.，Porter，T. F.，Oh，S. F. and Spite，M.，Maresins：novel macrophage mediators with potent antiinflammatory and proresolving actions.J Exp Med，2009，206：15-23.

32. Bratton，D.L.and Henson，P.M.，Neutrophil clearance：when the party is over，clean-up begins.Trends Immunol，2011，32：350-357.

33. Geering，B.，Gurzeler，U.，Federzoni，E.，Kaufmann，T.and Simon，H.U.，A novel TNFR1-triggered apoptosis pathway mediated by class IA PI3Ks in neutrophils. Blood，2011，117：5953-5962.

34. Siegel，R.M.，Caspases at the crossroads of immune-cell life and death.Nat Rev Immunol 2006.6：308-317.

35. Acehan，D.，Jiang，X.，Morgan，D.G.，Heuser，J.E.，Wang，X.and Akey，C.W.，Three-dimensional structure of the apoptosome：implications for assembly，procaspase-9 binding，and activation.Mol Cell，2002，9：423-432.

36. Vanhaesebroeck，B.，Stephens，L. and Hawkins，P.，PI3K signalling：the path to discovery and understanding.Nat Rev Mol Cell Biol，2012，13：195-203.

37. Russo，R.C.，Garcia，C.C.，Barcelos，L.S.，Rachid，M.A.，Guabiraba，R.，Roffe，E.，Souza，A.L.，Sousa，L.P.，Mirolo，M.，Doni，A.，Cassali，G.D.，Pinho，V.，Locati，M.and Teixeira，M.M.，Phosphoinositide 3-kinase gamma plays a critical role in bleomycin-induced pulmonary inflammation and fibrosis in mice.J Leukoc Biol，2011，89：269-282.

38. Pinho，V.，Russo，R.C.，Amaral，F.A.，de Sousa，L.P.，Barsante，M.M.，de Souza，D.G.，Alves-Filho，J.C.，Cara，D.C.，Hayflick，J. S.，Rommel，C.，Ruckle，T.，Rossi，A. G. and Teixeira，M. M.，Tissue-and stimulus-dependent role of phosphatidylinositol 3-kinase isoforms for neutrophil recruitment induced by chemoattractants in vivo.J Immunol，2007，179：7891-7898.

39. Kaminska，B.，MAPK signalling pathways as molecular targets for anti-inflammatory therapy-from molecular mechanisms to therapeutic benefits.Biochim Biophys Acta，2005，1754：253-262.

40. Saba-El-Leil，M. K.，Vella，F. D.，Vernay，B.，Voisin，L.，Chen，L.，Labrecque，N.，Ang，S.L.and Meloche，S.，An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development.EMBO Rep，2003，4：964-968.

41. Pearson，G.，Robinson，F.，Beers Gibson，T.，Xu，B. E.，Karandikar，M.，Berman，K.and Cobb，M.H.，Mitogen-activated protein（MAP）kinase pathways：regulation and physiological functions.Endocr Rev，2001，22：153-183.

42. Sawatzky，D.A.，Willoughby，D.A.，Colville-Nash，P.R.and Rossi，A.G.，The involvement of the apoptosis-modulating proteins ERK 1/2，Bcl-xL and Bax in the resolution of acute inflammation in vivo.Am J Pathol，2006，168：33-41.

43. Yang，Y.H.，Toh，M.L.，Clyne，C.D.，Leech，M.，Aeberli，D.，Xue，J.，Dacumos，A.，Sharma，L.and Morand，E.F.，Annexin 1 negatively regulates IL-6 expression via effects on p38 MAPK and MAPK phosphatase-1. J Immunol，2006，177：8148-8153.

44. El Kebir，D.，Jozsef，L.，Khreiss，T.，Pan，W.，Petasis，N. A.，Serhan，C.N.and Filep，J.G.，Aspirin-triggered lipoxins override the apoptosis-delaying action of serum amyloid A in human neutrophils：a novel mechanism for resolution of inflammation.J Immunol，2007，179：616-622.

45. Cory，S.and Adams，J.M.，The Bcl2 family：regulators of the cellular life-or-death switch.Nat Rev Cancer，2002，2：647-656.

46. Cross，A.，Moots，R.J.and Edwards，S.W.，The dual effects of TNF alpha on neutrophil apoptosis are mediated via differential effects on expression of Mcl-1 and Bfl-1. Blood，2008，111：878-884.

47. Wardle，D.J.，Burgon，J.，Sabroe，I.，Bingle，C.D.，Whyte，M.K.and Renshaw，S.A.，Effective caspase inhibition blocks neutrophil apoptosis and reveals Mcl-1 as both a regulator and a target of neutrophil caspase activation. PLoS One，2011，6：e15768.

48. Gregory，C.D.and Pound，J.D.，Microenvironmental influences of apoptosis in vivo and in vitro.Apoptosis，2010，15：1029-1049.

49. Gregory，C.D.，Rossi，A.G.，Bournazou，I.，Zhuang，L.and Willems，J.J.，Leukocyte migratory responses to apoptosis：the attraction and the distraction.Cell Adh Migr，2011，5：293-297.

50. Marques，P.E.，Amaral，S.S.，Pires，D.A.，Nogueira，L.L.，Soriani，F.M.，Lima，B.H.，Lopes，G.A.，Russo，R.C.，Avila，T.V.，Melgaco，J.G.，Oliveira，A.G.，Pinto，M.A.，Lima，C. X.，De Paula，A.M.，Cara，D.C.，Leite，M.F.，Teixeira，M.M. and Menezes，G.B.，Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure.Hepatology，2012，56：1971-1982.

51. Bournazou，I.，Pound，J.D.，Duffin，R.，Bournazos，S.，Melville，L.A.，Brown，S.B.，Rossi，A.G.and Gregory，C.D.，Apoptotic human cells inhibit migration of granulocytes via release of lactoferrin.J Clin Invest，2009，119：20-32.

52. Liu，G.，Xia，X. P.，Gong，S. L. and Zhao，Y.，The macrophage heterogeneity：difference between mouse peritoneal exudate and splenic F4/80+ macrophages.J Cell Physiol，2006，209：341-352.

53. Gordon，S.，Alternative activation of macrophages.Nat Rev Immunol，2003，3：23-35.

54. Ariel，A.and Serhan，C.N.，New Lives Given by Cell Death：Macrophage Differentiation Following Their Encounter with Apoptotic Leukocytes during the Resolution of Inflammation.Front Immunol，2012，3：4.

55. Ramachandran，P.，Pellicoro，A.，Vernon，M. A.，Boulter，L.，Aucott，R.L.，Ali，A.，Hartland，S.N.，Snowdon，V.K.，Cappon，A.，Gordon-Walker，T.T.，Williams，M.J.，Dunbar，D.R.，Manning，J. R.，van Rooijen，N.，Fallowfield，J. A.，Forbes，S.J.and Iredale，J.P.，Differential Ly-6C expression identifies the recruited macrophage phenotype，which orchestrates the regression of murine liver fibrosis.Proc Natl Acad Sci U S A，2012，109：E3186-3195.

56. Gregory，C.D.and Pound，J.D.，Cell death in the neighbourhood：direct microenvironmental effects of apoptosis in normal and neoplastic tissues.J Pathol，2011，223：177-194.

57. Yazdi，A.S.，Guarda，G.，D’Ombrain，M.C.and Drexler，S. K.，Inflammatory caspases in innate immunity and inflammation.J Innate Immun，2010，2：228-237.

58. Titos，E.，Rius，B.，Gonzalez-Periz，A.，Lopez-Vicario，C.，Moran-Salvador，E.，Martinez-Clemente，M.，Arroyo，V.and Claria，J.，Resolvin D1 and its precursor docosahexaenoic acid promote resolution of adipose tissue inflammation by eliciting macrophage polarization toward an M2-like phenotype.J Immunol，2011，187：5408-5418.

59. Dalli，J.，Zhu，M.，Vlasenko，N.A.，Deng，B.，Haeggstrom，J. Z.，Petasis，N.A.and Serhan，C.N.，The novel 13S，14S-epoxy-maresin is converted by human macrophages to maresin 1（MaR1），inhibits leukotriene A4 hydrolase（LTA4H），and shifts macrophage phenotype.FASEB J，2013，27：2573-2583.