肿瘤热点关注
上QQ阅读APP看书,第一时间看更新

参考文献

[1]Parkin D M,Bray F,Ferlay J,et al.Global cancer statistics,2002.CA Cancer J Clin,2005,55(2):74-108.
[2]Pisani P,Parkin D M,Bray F,et al.Erratum:Estimates of the worldwide mortality from 25cancers in 1990.Int J Cancer,1999,83(6):870-873.
[3]Haidari M,Nikbakht M R,Pasdar Y,et al.Trend analysis of gastric cancer incidence in Iran and its six geographical areas during 2000-2005.Asian Pac J Cancer Prev,2012,13(7):3335-3341.
[4]Jemal A,Bray F,Center M M,et al.Global cancer statistics.CA Cancer J Clin,2011,61(2):69-90.
[5]Price T J,Shapiro J D,Segelov E,et al.Management of advanced gastric cancer.Expert Rev Gastroenterol Hepatol,2012,6(2):199-208,209.
[6]Hanahan D,Weinberg R A.Hallmarks of cancer:the next generation.Cell,2011,144(5):646-674.
[7]Hanahan D,Weinberg R A.The hallmarks of cancer.Cell,2000,100(1):57-70.
[8]Ponder B A.Cancer genetics.Nature,2001,411(6835):336-341.
[9]Wang K,Kan J,Yuen S T,et al.Exome sequencing identifies frequent mutation of ARID1Ain molecular subtypes of gastric cancer.Nat Genet,2011,43(12):1219-1223.
[10]Mousavi S M,Gouya M M,Ramazani R,et al.Cancer incidence and mortality in Iran.Ann Oncol,2009,20(3):556-563.
[11]Eskandar H,Hossein S S,Rahim M,et al.Clinical profile of gastric cancer in Khuzestan,southwest of Iran.World J Gastroenterol,2006,12(30):4832-4835.
[12]Ghadimi R,Taheri H,Suzuki S,et al.Host and environmental factors for gastric cancer in Babol,the Caspian Sea Coast,Iran.Eur J Cancer Prev,2007,16(3):192-195.
[13]Chandanos E,Lagergren J.Oestrogen and the enigmatic male predominance of gastric cancer.Eur J Cancer,2008,44(16):2397-2403.
[14]Malekzadeh R,Sotoudeh M,Derakhshan M H,et al.Prevalence of gastric precancerous lesions in Ardabil,a high incidence province for gastric adenocarcinoma in the northwest of Iran.J Clin Pathol,2004,57(1):37-42.
[15]Malekzadeh R,Derakhshan M H,Malekzadeh Z.Gastric cancer in Iran:epidemiology and risk factors.Arch Iran Med,2009,12(6):576-583.
[16]Sadjadi A,Hislop T G,Bajdik C,et al.Comparison of breast cancer survival in two populations:Ardabil,Iran and British Columbia,Canada.BMC Cancer,2009,9:381.
[17]Saeki N,Ono H,Sakamoto H,et al.Genetic factors related to gastric cancer susceptibility identified using agenome-wide association study.Cancer Sci,2013,104(1):1-8.
[18]Coupland V H,Lagergren J,Konfortion J,et al.Ethnicity in relation to incidence of oesophageal and gastric cancer in England.Br J Cancer,2012,107(11):1908-1914.
[19]Sasazuki S,Sasaki S,Tsugane S.Cigarette smoking,alcohol consumption and subsequent gastric cancer risk by subsite and histologic type.Int J Cancer,2002,101(6):560-566.
[20]Steevens J,Schouten L J,Goldbohm R A,et al.Alcohol consumption,cigarette smoking and risk of subtypes of oesophageal and gastric cancer:aprospective cohort study.Gut,2010,59(1):39-48.
[21]Bertuccio P,Chatenoud L,Levi F,et al.Recent patterns in gastric cancer:aglobal overview.Int J Cancer,2009,125(3):666-673.
[22]Sjodahl K,Lu Y,Nilsen T I,et al.Smoking and alcohol drinking in relation to risk of gastric cancer:a population-based,prospective cohort study.Int J Cancer,2007,120(1):128-132.
[23]Shin V Y,Cho C H.Nicotine and gastric cancer.Alcohol,2005,35(3):259-264.
[24]Huang R Y,Chen G G.Cigarette smoking,cyclooxygenase-2pathway and cancer.Biochim Biophys Acta,2011,1815(2):158-169.
[25]Zhang Y,Sun L P,Xing C Z,et al.Interaction between GSTP1Val allele and H.pylori infection,smoking and alcohol consumption and risk of gastric cancer among the Chinese population.PLoS One,2012, 7(10):e47178.
[26]Everatt R,Tamosiunas A,Kuzmickiene I,et al.Alcohol consumption and risk of gastric cancer:a cohort study of men in Kaunas,Lithuania,with up to 30years follow-up.BMC Cancer,2012,12:475.
[27]Moy K A,Fan Y,Wang R,et al.Alcohol and tobacco use in relation to gastric cancer:aprospective study of men in Shanghai,China.Cancer Epidemiol Biomarkers Prev,2010,19(9):2287-2297.
[28]Duell E J,Travier N,Lujan-Barroso L,et al.Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition(EPIC)cohort.Am J Clin Nutr,2011,94(5):1266-1275.
[29]Tramacere I,Negri E,Pelucchi C,et al.A meta-analysis on alcohol drinking and gastric cancer risk.Ann Oncol,2012,23(1):28-36.
[30]Klatsky A L.Diet,alcohol,and health:a story of connections,confounders,and cofactors.Am J Clin Nutr,2001,74(3):279-280.
[31]Ding W Q,Fried U,Larsson C,et al.Ethanol exposure potentiates fosB and junB expression induced by muscarinic receptor stimulation in neuroblastoma SH-SY5Ycells.Alcohol Clin Exp Res,1998,22(1):225-230.
[32]Huang B,Liu B,Yang L,et al.Functional genetic variants of c-Jun and their interaction with smoking and drinking increase the susceptibility to lung cancer in southern and eastern Chinese.Int J Cancer,2012,131(5):E744-E758.
[33]Chang Y J,Wu M S,Lin J T,et al.Helicobacter pylori-Induced invasion and angiogenesis of gastric cells is mediated by cyclooxygenase-2induction through TLR2/TLR9and promoter regulation.J Immunol,2005,175(12):8242-8252.
[34]Gajalakshmi C K,Shanta V.Lifestyle and risk of stomach cancer:a hospital-based case-control study.Int J Epidemiol,1996,25(6):1146-1153.
[35]Chow W H,Swanson C A,Lissowska J,et al.Risk of stomach cancer in relation to consumption of cigarettes,alcohol,tea and coffee in Warsaw,Poland.Int J Cancer,1999,81(6):871-876.
[36]Wu A H,Wan P,Bernstein L.A multiethnic population-based study of smoking,alcohol and body size and risk of adenocarcinomas of the stomach and esophagus(United States).Cancer Causes Control,2001,12(8):721-732.
[37]Rao D N,Ganesh B,Dinshaw K A,et al.A case-control study of stomach cancer in Mumbai,India.Int J Cancer,2002,99(5):727-731.
[38]Barstad B,Sorensen T I,Tjonneland A,et al.Intake of wine,beer and spirits and risk of gastric cancer.Eur J Cancer Prev,2005,14(3):239-243.
[39]Larsson S C,Giovannucci E,Wolk A.Alcoholic beverage consumption and gastric cancer risk:aprospective population-based study in women.Int J Cancer,2007,120(2):373-377.
[40]Kaneko S,Yoshimura T.Time trend analysis of gastric cancer incidence in Japan by histological types,1975-1989.Br J Cancer,2001,84(3):400-405.
[41]D′Elia L,Rossi G,Ippolito R,et al.Habitual salt intake and risk of gastric cancer:a meta-analysis of prospective studies.Clin Nutr,2012,31(4):489-498.
[42]Zhong C,Li K N,Bi J W,et al.Sodium intake,salt taste and gastric cancer risk according to helicobacter pylori infection,smoking,histological type and tumor site in china.Asian Pac J Cancer Prev,2012,13 (6):2481-2484.
[43]Kim J,Park S,Nam B H.Gastric cancer and salt preference:apopulation-based cohort study in Korea.Am J Clin Nutr,2010,91(5):1289-1293.
[44]Xiao S D,Jiang S J,Wang R N,et al.N-ethyl-N′-nitro-N-nitrosoguanidine induced gastric carcinoma in wolfdogs--useful animal model for tracing gastric malignancy transformation.Chin Med J(Engl),1986,99(11):903-907.
[45]Moret S,Conte L,Dean D.Assessment of polycyclic aromatic hydrocarbon content of smoked fish by means of a fast HPLC/HPLC method.J Agric Food Chem,1999,47(4):1367-1371.
[46]Lopez-Carrillo L,Lopez-Cervantes M,Ward M H,et al.Nutrient intake and gastric cancer in Mexico.Int J Cancer,1999,83(5):601-605.
[47]Azevedo L F,Salgueiro L F,Claro R,et al.Diet and gastric cancer in Portugal--a multivariate model.Eur J Cancer Prev,1999,8(1):41-48.
[48]Chen J,Bu X L,Wang Q Y,et al.Decreasing seroprevalence of Helicobacter pylori infection during 1993-2003in Guangzhou,southern China.Helicobacter,2007,12(2):164-169.
[49]Kawakami E,Machado R S,Ogata S K,et al.Decrease in prevalence of Helicobacter pylori infection during a 10-year period in Brazilian children.Arq Gastroenterol,2008,45(2):147-151.
[50]Tkachenko M A,Zhannat N Z,Erman L V,et al.Dramatic changes in the prevalence of Helicobacter pylori infection during childhood:a 10-year follow-up study in Russia.J Pediatr Gastroenterol Nutr,2007,45(4):428-432.
[51]La Vecchia C,Negri E,D′Avanzo B,et al.Electric refrigerator use and gastric cancer risk.Br J Cancer,1990,62(1):136-137.
[52]Katz L,Steinitz R.Cancer patterns in Israel:selected aspects.Isr J Med Sci,1979,15(12):983-989.
[53]Demirer T,Icli F,Uzunalimoglu O,et al.Diet and stomach cancer incidence.A case-control study in Turkey.Cancer,1990,65(10):2344-2348.
[54]Kim H J,Chang W K,Kim M K,et al.Dietary factors and gastric cancer in Korea:a case-control study.Int J Cancer,2002,97(4):531-535.
[55]Matsuzaka M,Fukuda S,Takahashi I,et al.The decreasing burden of gastric cancer in Japan.Tohoku J Exp Med,2007,212(3):207-219.
[56]Zhou Y,Zhuang W,Hu W,et al.Consumption of large amounts of Allium vegetables reduces risk for gastric cancer in a meta-analysis.Gastroenterology,2011,141(1):80-89.
[57]Terry P,Lagergren J,Hansen H,et al.Fruit and vegetable consumption in the prevention of oesophageal and cardia cancers.Eur J Cancer Prev,2001,10(4):365-369.
[58]Kim M K,Sasaki S,Sasazuki S,et al.Prospective study of three major dietary patterns and risk of gastric cancer in Japan.Int J Cancer,2004,110(3):435-442.
[59]Yang C S,Lee M J,Chen L,et al.Polyphenols as inhibitors of carcinogenesis.Environ Health Perspect,1997,105(Suppl 4):971-976.
[60]Weisburger J H,Chung F L.Mechanisms of chronic disease causation by nutritional factors and tobacco products and their prevention by tea polyphenols.Food Chem Toxicol,2002,40(8):1145-1154.
[61]Kono S,Ikeda M,Tokudome S,et al.A case-control study of gastric cancer and diet in northern Kyushu,Japan.Jpn J Cancer Res,1988,79(10):1067-1074.
[62]Ikeda F,Doi Y,Yonemoto K,et al.Hyperglycemia increases risk of gastric cancer posed by Helicobacter pylori infection:apopulation-based cohort study.Gastroenterology,2009,136(4):1234-1241.
[63]Chen Y L,Cheng K C,Lai S W,et al.Diabetes and risk of subsequent gastric cancer:apopulation-based cohort study in Taiwan.Gastric Cancer,2013,16(3):389-396.
[64]An international association between Helicobacter pylori infection and gastric cancer.The EUROGAST Study Group.Lancet,1993,341(8857):1359-1362.
[65]Gonzalez C A,Agudo A.Carcinogenesis,prevention and early detection of gastric cancer:where we are and where we should go.Int J Cancer,2012,130(4):745-753.
[66]Oliveira A G,Santos A,Guerra J B,et al.babA2-and cagA-positive Helicobacter pylori strains are associated with duodenal ulcer and gastric carcinoma in Brazil.J Clin Microbiol,2003,41(8):3964-3966.
[67]Al-Marhoon M S,Nunn S,Soames R W.The association between cagA+H.pylori infection and distal gastric cancer:aproposed model.Dig Dis Sci,2004,49(7-8):1116-1122.
[68]Pirzadeh A,Doustmohammadian N,Khoshbaten M,et al.Is there any association between Helicobacter Pylori infection and laryngeal carcinoma?Asian Pac J Cancer Prev,2011,12(4):897-900.
[69]Wong B C,Lam S K,Wong W M,et al.Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China:a randomized controlled trial.JAMA,2004,291(2):187-194.
[70]Guilford P,Hopkins J,Harraway J,et al.E-cadherin germline mutations in familial gastric cancer.Nature,1998,392(6674):402-405.
[71]Kato M,Asaka M.Recent development of gastric cancer prevention.Jpn J Clin Oncol,2012,42(11):987-994.
[72]Haruma K.Trend toward a reduced prevalence of Helicobacter pylori infection,chronic gastritis,and gastric cancer in Japan.Gastroenterol Clin North Am,2000,29(3):623-631.
[73]Fukase K,Kato M,Kikuchi S,et al.Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer:an open-label,randomised controlled trial.Lancet,2008,372(9636):392-397.
[74]Held M,Engstrand L,Hansson L E,et al.Is the association between Helicobacter pylori and gastric cancer confined to CagA-positive strains?Helicobacter,2004,9(3):271-277.
[75]Ohnishi N,Yuasa H,Tanaka S,et al.Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse.Proc Natl Acad Sci U S A,2008,105(3):1003-1008.
[76]Chaturvedi R,Asim M,Romero-Gallo J,et al.Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA.Gastroenterology,2011,141(5):1696-1708.
[77]Asahi M,Azuma T,Ito S,et al.Helicobacter pylori CagA protein can be tyrosine phosphorylated in gastric epithelial cells.J Exp Med,2000,191(4):593-602.
[78]Konturek P C,Konturek S J,Brzozowski T.Helicobacter pylori infection in gastric cancerogenesis.J Physiol Pharmacol,2009,60(3):3-21.
[79]Galmiche A,Rassow J,Doye A,et al.The N-terminal 34kDa fragment of Helicobacter pylori vacuolating cytotoxin targets mitochondria and induces cytochrome c release.EMBO J,2000,19(23):6361-6370.
[80]Yuan J P,Li T,Chen H B,et al.Analysis of gene expression profile in gastric cancer cells stimulated with Helicobacter pylori isogenic strains.J Med Microbiol,2004,53(Pt 10):965-974.
[81]Yamaoka Y,Kikuchi S,El-Zimaity H M,et al.Importance of Helicobacter pylori oipA in clinical presentation,gastric inflammation,and mucosal interleukin 8production.Gastroenterology,2002,123(2):414-424.
[82]Kidd M,Peek R M,Lastovica A J,et al.Analysis of iceA genotypes in South African Helicobacter pylori strains and relationship to clinically significant disease.Gut,2001,49(5):629-635.
[83]Koehler C I,Mues M B,Dienes H P,et al.Helicobacter pylori genotyping in gastric adenocarcinoma and MALT lymphoma by multiplex PCR analyses of paraffin wax embedded tissues.Mol Pathol,2003,56 (1):36-42.
[84]Sureka C,Ramesh T.Molecular assessment of c-H-ras p21expression in Helicobacter pylori-mediated gastric carcinogenesis.Mol Cell Biochem,2012,362(1-2):169-176.
[85]Imazeki F,Omata M,Nose H,et al.p53gene mutations in gastric and esophageal cancers.Gastroenterology,1992,103(3):892-896.
[86]Perri F,Cotugno R,Piepoli A,et al.Aberrant DNA methylation in non-neoplastic gastric mucosa of H.Pylori infected patients and effect of eradication.Am J Gastroenterol,2007,102(7):1361-1371.
[87]Honig A,Witte F,Mirecka J,et al.Helicobacter pylori-induced hyperproliferation:relevance for gastric cancer development in connection with mutagenic factors.Anticancer Res,2000,20(3A):1641-1648.
[88]Lynch D A,Mapstone N P,Clarke A M,et al.Cell proliferation in Helicobacter pylori associated gastritis and the effect of eradication therapy.Gut,1995,36(3):346-350.
[89]Suzuki N,Wakasugi M,Nakaya S,et al.Production and application of new monoclonal antibodies specific for a fecal Helicobacter pylori antigen.Clin Diagn Lab Immunol,2002,9(1):75-78.
[90]Beswick E J,Pinchuk I V,Suarez G,et al.Helicobacter pylori CagA-dependent macrophage migration inhibitory factor produced by gastric epithelial cells binds to CD74and stimulates procarcinogenic events.J Immunol,2006,176(11):6794-6801.
[91]Wang J,Fan X,Lindholm C,et al.Helicobacter pylori modulates lymphoepithelial cell interactions leading to epithelial cell damage through Fas/Fas ligand interactions.Infect Immun,2000,68(7):4303-4311.
[92]郭燕,周新家.HP感染与胃癌组织中Caspase-3表达的关系.山东医药,2008,48(36):76-77.
[93]Targosz A,Brzozowski T,Pierzchalski P,et al.Helicobacter pylori promotes apoptosis,activates cyclooxygenase(COX)-2and inhibits heat shock protein HSP70in gastric cancer epithelial cells.Inflamm Res,2012,61(9):955-966.
[94]Chang C S,Chen W N,Lin H H,et al.Increased oxidative DNA damage,inducible nitric oxide synthase,nuclear factor kappaB expression and enhanced antiapoptosis-related proteins in Helicobacter pylori-infected non-cardiac gastric adenocarcinoma.World J Gastroenterol,2004,10(15):2232-2240.
[95]Wu C Y,Wang C J,Tseng C C,et al.Helicobacter pylori promote gastric cancer cells invasion through a NF-kappaB and COX-2-mediated pathway.World J Gastroenterol,2005,11(21):3197-3203.
[96]Hou L,Savage S A,Blaser M J,et al.Telomere length in peripheral leukocyte DNA and gastric cancer risk.Cancer Epidemiol Biomarkers Prev,2009,18(11):3103-3109.
[97]Nardone G,Staibano S,Rocco A,et al.Effect of Helicobacter pylori infection and its eradication on cell proliferation,DNA status,and oncogene expression in patients with chronic gastritis.Gut,1999,44(6):789-799.
[98]Cheng Y,Chaturvedi R,Asim M,et al.Helicobacter pylori-induced macrophage apoptosis requires activation of ornithine decarboxylase by c-Myc.J Biol Chem,2005,280(23):22492-22496.
[99]Wang J,Chi D S,Kalin G B,et al.Helicobacter pylori infection and oncogene expressions in gastric carcinoma and its precursor lesions.Dig Dis Sci,2002,47(1):107-113.
[100]Churin Y,Al-Ghoul L,Kepp O,et al.Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response.J Cell Biol,2003,161(2):249-255.
[101]Kabir S.Effect of Helicobacter pylori eradication on incidence of gastric cancer in human and animal models:underlying biochemical and molecular events.Helicobacter,2009,14(3):159-171.
[102]Shirin H,Sordillo E M,Kolevska T K,et al.Chronic Helicobacter pylori infection induces an apoptosis-resistant phenotype associated with decreased expression of p27(kip1).Infect Immun,2000,68(9):5321-5328.
[103]石巍,姚育红,廖爱军,等.不同胃黏膜病变中幽门螺杆菌感染与环氧合酶表达相关性分析.中华消化杂志,2004,24(12):750-751.
[104]Nam K T,Hahm K B,Oh S Y,et al.The selective cyclooxygenase-2inhibitor nimesulide prevents Helicobacter pylori-associated gastric cancer development in a mouse model.Clin Cancer Res,2004,10 (23):8105-8113.
[105]Iwamoto J,Mizokami Y,Takahashi K,et al.The effects of cyclooxygenase2-prostaglandinE2pathway on Helicobacter pylori-induced urokinase-type plasminogen activator system in the gastric cancer cells.Helicobacter,2008,13(3):174-182.
[106]Konturek P C,Kania J,Kukharsky V,et al.Influence of gastrin on the expression of cyclooxygenase-2,hepatocyte growth factor and apoptosis-related proteins in gastric epithelial cells.J Physiol Pharmacol,2003,54(1):17-32.
[107]Walduck A K,Weber M,Wunder C,et al.Identification of novel cyclooxygenase-2-dependent genes in Helicobacter pylori infection in vivo.Mol Cancer,2009,8:22.
[108]林瑞新,任辉,田立业,等.Hp阳性胃癌患者PG及胃泌素水平的研究.中国实验诊断学,2007,11:1250-1251.
[109]Subramaniam D,Ramalingam S,May R,et al.Gastrin-mediated interleukin-8and cyclooxygenase-2 gene expression:differential transcriptional and posttranscriptional mechanisms.Gastroenterology,2008,134(4):1070-1082.
[110]Konturek P C,Konturek S J,Brzozowski T.Gastric cancer and Helicobacter pylori infection.J Physiol Pharmacol,2006,57(Suppl 3):51-65.
[111]Soh K,Yanagisawa A,Hiratsuka H,et al.Variation in K-ras codon 12point mutation rate with histological atypia within individual colorectal tumors.Jpn J Cancer Res,1993,84(4):388-393.
[112]顾华丽,董静.胃癌组织中H-ras及K-ras基因第12密码子点突变的检测及意义.青岛大学医学院学报,2006,42(1):56-60.
[113]Hunt J D,Mera R,Strimas A,et al.K-ras mutations are not predictive for progression of preneoplastic gastric lesions.Cancer Epidemiol Biomarkers Prev,2001,10(1):79-80.
[114]Schubbert S,Shannon K,Bollag G.Hyperactive Ras in developmental disorders and cancer.Nat Rev Cancer,2007,7(4):295-308.
[115]Kim M A,Lee H S,Lee H E,et al.EGFR in gastric carcinomas:prognostic significance of protein overexpression and high gene copy number.Histopathology,2008,52(6):738-746.
[116]Morrison H,Sperka T,Manent J,et al.Merlin/neurofibromatosis type 2suppresses growth by inhibiting the activation of Ras and Rac.Cancer Res,2007,67(2):520-527.
[117]Orian-Rousseau V,Morrison H,Matzke A,et al.Hepatocyte growth factor-induced Ras activation requires ERM proteins linked to both CD44v6and F-actin.Mol Biol Cell,2007,18(1):76-83.
[118]Lam E K,Wang X,Shin V Y,et al.A microRNA contribution to aberrant Ras activation in gastric cancer.Am J Transl Res,2011,3(2):209-218.
[119]Keates S,Sougioultzis S,Keates A C,et al.cag+Helicobacter pylori induce transactivation of the epidermal growth factor receptor in AGS gastric epithelial cells.J Biol Chem,2001,276(51):48127-48134.
[120]Sarbia M,Porschen R,Borchard F,et al.p53protein expression and prognosis in squamous cell carcinoma of the esophagus.Cancer,1994,74(8):2218-2223.
[121]Petitjean A,Mathe E,Kato S,et al.Impact of mutant p53functional properties on TP53mutation patterns and tumor phenotype:lessons from recent developments in the IARC TP53database.Hum Mutat,2007,28(6):622-629.
[122]Mattar R,Nonogaki S,Silva C,et al.P53and Rb tumor suppressor gene alterations in gastric cancer.Rev Hosp Clin Fac Med Sao Paulo,2004,59(4):172-180.
[123]Fenoglio-Preiser C M,Wang J,Stemmermann G N,et al.TP53and gastric carcinoma:a review.Hum Mutat,2003,21(3):258-270.
[124]Uchino S,Noguchi M,Ochiai A,et al.p53mutation in gastric cancer:agenetic model for carcinogenesis is common to gastric and colorectal cancer.Int J Cancer,1993,54(5):759-764.
[125]Goncalves A R,Carneiro A J,Martins I,et al.Prognostic significance of p53protein expression in early gastric cancer.Pathol Oncol Res,2011,17(2):349-355.
[126]Shen H,Solari A,Wang X,et al.P53codon 72polymorphism and risk of gastric cancer in a Chinese population.Oncol Rep,2004,11(5):1115-1120.
[127]Kim J M,Lee O Y,Lee C G,et al.p53Codon 72and 16-bp duplication polymorphisms of gastric cancer in Koreans,.Korean J Gastroenterol,2007,50(5):292-298.
[128]Serrano M,Hannon G J,Beach D.A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.Nature,1993,366(6456):704-707.
[129]Kamb A,Gruis N A,Weaver-Feldhaus J,et al.A cell cycle regulator potentially involved in genesis of many tumor types.Science,1994,264(5157):436-440.
[130]Otterson G A,Kratzke R A,Coxon A,et al.Absence of p16INK4protein is restricted to the subset of lung cancer lines that retains wildtype RB.Oncogene,1994,9(11):3375-3378.
[131]Newcomb E W,Alonso M,Sung T,et al.Incidence of p14ARF gene deletion in high-grade adult and pediatric astrocytomas.Hum Pathol,2000,31(1):115-119.
[132]Ding Y,Le XP,Zhang Q X,et al.Methylation and mutation analysis of p16gene in gastric cancer.World J Gastroenterol,2003,9(3):423-426.
[133]He X S,Su Q,Chen Z C,et al.Expression,deletion[was deleton]and mutation of p16gene in human gastric cancer.World J Gastroenterol,2001,7(4):515-521.
[134]范开席,王哲海,胡伟.p16、CD44V6和nm23-H1基因在胃癌中的表达.中华消化杂志,2001,21(6):375-376.
[135]Hino R,Uozaki H,Murakami N,et al.Activation of DNA methyltransferase 1by EBV latent membrane protein 2Aleads to promoter hypermethylation of PTEN gene in gastric carcinoma.Cancer Res,2009,69(7):2766-2774.
[136]Waite K A,Eng C.Protean PTEN:form and function.Am J Hum Genet,2002,70(4):829-844.
[137]Zhang B G,Li J F,Yu B Q,et al.microRNA-21promotes tumor proliferation and invasion in gastric cancer by targeting PTEN.Oncol Rep,2012,27(4):1019-1026.
[138]Xiong X,Ren H Z,Li M H,et al.Down-regulated miRNA-214induces a cell cycle G1arrest in gastric cancer cells by up-regulating the PTEN protein.Pathol Oncol Res,2011,17(4):931-937.
[139]Yang Z,Yuan X G,Chen J,et al.Reduced expression of PTEN and increased PTEN phosphorylation at residue Ser380in gastric cancer tissues:A novel mechanism of PTEN inactivation.Clin Res Hepatol Gastroenterol,2013,37(1):72-79.
[140]Wang D S,Rieger-Christ K,Latini J M,et al.Molecular analysis of PTEN and MXI1in primary bladder carcinoma.Int J Cancer,2000,88(4):620-625.
[141]Parkin D M.Global cancer statistics in the year 2000.Lancet Oncol,2001,2(9):533-543.
[142]Chen X Y,van Der Hulst R W,Shi Y,et al.Comparison of precancerous conditions:atrophy and intestinal metaplasia in Helicobacter pylori gastritis among Chinese and Dutch patients.J Clin Pathol,2001, 54(5):367-370.
[143]Kondo K,Yao M,Kobayashi K,et al.PTEN/MMAC1/TEP1mutations in human primary renal-cell carcinomas and renal carcinoma cell lines.Int J Cancer,2001,91(2):219-224.
[144]Koul D,Parthasarathy R,Shen R,et al.Suppression of matrix metalloproteinase-2gene expression and invasion in human glioma cells by MMAC/PTEN.Oncogene,2001,20(46):6669-6678.
[145]Huang J,Kontos C D.PTEN modulates vascular endothelial growth factor-mediated signaling and angiogenic effects.J Biol Chem,2002,277(13):10760-10766.
[146]Byzova T V,Goldman C K,Pampori N,et al.A mechanism for modulation of cellular responses to VEGF:activation of the integrins.Mol Cell,2000,6(4):851-860.
[147]Bao R,Connolly D C,Murphy M,et al.Activation of cancer-specific gene expression by the survivin promoter.J Natl Cancer Inst,2002,94(7):522-528.
[148]Wenying Z,Zhaoning J,Zhimin Y,et al.Survivin siRNA inhibits gastric cancer in nude mice.Cell Biochem Biophys,2012,62(2):337-341.
[149]Tamm I,Wang Y,Sausville E,et al.IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas(CD95),Bax,caspases,and anticancer drugs.Cancer Res,1998,58(23):5315-5320.
[150]Shin S,Sung B J,Cho Y S,et al.An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3and-7.Biochemistry,2001,40(4):1117-1123.
[151]Cao W,Fan R,Wang L,et al.Expression and regulatory function of miRNA-34ain targeting survivin in gastric cancer cells.Tumour Biol,2012.
[152]邓昊,黄萱,高友晶,等.IFN-γ对人胃腺癌Survivin分子通路的调控作用.世界华人消化杂志,2010,18(30):3249-3253.
[153]Deng H,Zhen H,Fu Z,et al.The antagonistic effect between STAT1and Survivin and its clinical significance in gastric cancer.Oncol Lett,2012,3(1):193-199.
[154]Akiyama T,Sudo C,Ogawara H,et al.The product of the human c-erbB-2gene:a 185-kilodalton glycoprotein with tyrosine kinase activity.Science,1986,232(4758):1644-1646.
[155]Popescu N C,King C R,Kraus M H.Localization of the human erbB-2gene on normal and rearranged chromosomes 17to bands q12-21.32.Genomics,1989,4(3):362-366.
[156]Tanner M,Hollmen M,Junttila T T,et al.Amplification of HER-2in gastric carcinoma:association with TopoisomeraseⅡalpha gene amplification,intestinal type,poor prognosis and sensitivity to trastuzumab.Ann Oncol,2005,16(2):273-278.
[157]Rebischung C,Barnoud R,Stefani L,et al.The effectiveness of trastuzumab(Herceptin)combined with chemotherapy for gastric carcinoma with overexpression of the c-erbB-2protein.Gastric Cancer,2005,8(4):249-252.
[158]Jacobs J J,Scheijen B,Voncken J W,et al.Bmi-1collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF.Genes Dev,1999,13(20):2678-2690.
[159]Jacobs J J,Kieboom K,Marino S,et al.The oncogene and Polycomb-group gene bmi-1regulates cell proliferation and senescence through the ink4alocus.Nature,1999,397(6715):164-168.
[160]张晓伟,秦薇,郭伟剑,等.Bmi-1基因对胃癌细胞增殖的影响及机制.世界华人消化杂志,2009,17 (14):1390-1393.
[161]Zhang X W,Sheng Y P,Li Q,et al.BMI1and Mel-18oppositely regulate carcinogenesis and progression of gastric cancer.Mol Cancer,2010,9:40.
[162]Hicklin D J,Ellis L M.Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis.J Clin Oncol,2005,23(5):1011-1027.
[163]Halmaciu I,Gurzu S,Dobreanu M,et al.Preliminary results regarding vascular endothelial growth factor(VEGF-A)levels in the serum of gastric cancer patients.Rev Med Chir Soc Med Nat Iasi,2012,116 (2):446-451.
[164]Takashima S,Matsushita T,Takayama F,et al.Prognostic significance of magnetic resonance findings in advanced papillary thyroid cancer.Thyroid,2001,11(12):1153-1159.
[165]Joukov V,Pajusola K,Kaipainen A,et al.A novel vascular endothelial growth factor,VEGF-C,is a ligand for the Flt4(VEGFR-3)and KDR(VEGFR-2)receptor tyrosine kinases.EMBO J,1996,15 (7):1751.
[166]Cao Y,Linden P,Farnebo J,et al.Vascular endothelial growth factor C induces angiogenesis in vivo.Proc Natl Acad Sci U S A,1998,95(24):14389-14394.
[167]Amadio M,Scapagnini G,Lupo G,et al.PKCbetaⅡ/HuR/VEGF:A new molecular cascade in retinal pericytes for the regulation of VEGF gene expression.Pharmacol Res,2008,57(1):60-66.
[168]Essafi-Benkhadir K,Pouyssegur J,Pages G.Implication of the ERK pathway on the post-transcriptional regulation of VEGF mRNA stability.Methods Mol Biol,2010,661:451-469.
[169]Hyde R,Corkins M E,Somers G A,et al.PKC-1acts with the ERK MAPK signaling pathway to regulate Caenorhabditis elegans mechanosensory response.Genes Brain Behav,2011,10(3):286-298.
[170]He L F,Wang T T,Gao Q Y,et al.Stanniocalcin-1promotes tumor angiogenesis through up-regulation of VEGF in gastric cancer cells.J Biomed Sci,2011,18:39.
[171]Kim D K,Oh S Y,Kwon H C,et al.Clinical significances of preoperative serum interleukin-6and C-reactive protein level in operable gastric cancer.BMC Cancer,2009,9:155.
[172]Liao W C,Lin J T,Wu C Y,et al.Serum interleukin-6level but not genotype predicts survival after resection in stagesⅡandⅢgastric carcinoma.Clin Cancer Res,2008,14(2):428-434.
[173]Huang S P,Wu M S,Shun C T,et al.Interleukin-6increases vascular endothelial growth factor and angiogenesis in gastric carcinoma.J Biomed Sci,2004,11(4):517-527.
[174]Zhu B H,Zhan W H,Li Z R,et al.(-)-Epigallocatechin-3-gallate inhibits growth of gastric cancer by reducing VEGF production and angiogenesis.World J Gastroenterol,2007,13(8):1162-1169.
[175]Loeffler S,Fayard B,Weis J,et al.Interleukin-6induces transcriptional activation of vascular endothelial growth factor(VEGF)in astrocytes in vivo and regulates VEGF promoter activity in glioblastoma cells via direct interaction between STAT3and Sp1.Int J Cancer,2005,115(2):202-213.
[176]Zhu B H,Chen H Y,Zhan W H,et al.(-)-Epigallocatechin-3-gallate inhibits VEGF expression induced by IL-6via Stat3in gastric cancer.World J Gastroenterol,2011,17(18):2315-2325.
[177]Yu C L,Meyer D J,Campbell G S,et al.Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein.Science,1995,269(5220):81-83.
[178]Masuda M,Suzui M,Lim J T,et al.Epigallocatechin-3-gallate decreases VEGF production in head and neck and breast carcinoma cells by inhibiting EGFR-related pathways of signal transduction.J Exp Ther Oncol,2002,2(6):350-359.
[179]Sun P,Yu H,Zhang W Q,et al.Lentivirus-mediated siRNA targeting VEGF inhibits gastric cancer growth in vivo.Oncol Rep,2012,28(5):1687-1692.
[180]Folkman J.Tumor angiogenesis:therapeutic implications.N Engl J Med,1971,285(21):1182-1186.
[181]Wang Y,Fei D,Vanderlaan M,et al.Biological activity of bevacizumab,a humanized anti-VEGF antibody in vitro.Angiogenesis,2004,7(4):335-345.
[182]Ferrara N,Hillan K J,Gerber H P,et al.Discovery and development of bevacizumab,an anti-VEGF antibody for treating cancer.Nat Rev Drug Discov,2004,3(5):391-400.
[183]Wilhelm S M,Carter C,Tang L,et al.BAY 43-9006exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis.Cancer Res,2004,64(19):7099-7109.
[184]Wedge S R,Ogilvie D J,Dukes M,et al.ZD6474inhibits vascular endothelial growth factor signaling,angiogenesis,and tumor growth following oral administration.Cancer Res,2002,62(16):4645-4655.
[185]Herbst R S,Hong D,Chap L,et al.Safety,pharmacokinetics,and antitumor activity of AMG 386,a selective angiopoietin inhibitor,in adult patients with advanced solid tumors.J Clin Oncol,2009,27(21):3557-3565.
[186]Neal J,Wakelee H.AMG-386,a selective angiopoietin-1/-2-neutralizing peptibody for the potential treatment of cancer.Curr Opin Mol Ther,2010,12(4):487-495.
[187]Chen L,Li T,Li R,et al.Alphastatin downregulates vascular endothelial cells sphingosine kinase activity and suppresses tumor growth in nude mice bearing human gastric cancer xenografts.World J Gastroenterol,2006,12(26):4130-4136.
[188]Staton C A,Brown N J,Rodgers G R,et al.Alphastatin,a 24-amino acid fragment of human fibrinogen,is a potent new inhibitor of activated endothelial cells in vitro and in vivo.Blood,2004,103(2):601-606.
[189]Koyama Y,Okayama H,Kumamoto K,et al.Overexpression of endoglin(CD105)is associated with recurrence in radically resected gastric cancer.Exp Ther Med,2010,1(4):627-633.
[190]Tang H L,Hu Y Q,Qin X P,et al.Aplasia ras homolog member I is downregulated in gastric cancer and silencing its expression promotes cell growth in vitro.J Gastroenterol Hepatol,2012,27(8):1395-1404.
[191]刘爱东,庞久玲,刘士生.胃癌中基质金属蛋白酶-9和CD105表达关系的研究.中国老年学杂志,2009,29(7):886-887.
[192]Dallas N A,Samuel S,Xia L,et al.Endoglin(CD105):a marker of tumor vasculature and potential target for therapy.Clin Cancer Res,2008,14(7):1931-1937.
[193]Tsujie M,Tsujie T,Toi H,et al.Anti-tumor activity of an anti-endoglin monoclonal antibody is enhanced in immunocompetent mice.Int J Cancer,2008,122(10):2266-2273.
[194]Nakashima H,Natsugoe S,Ishigami S,et al.Clinical significance of nuclear expression of spleen tyrosine kinase(Syk)in gastric cancer.Cancer Lett,2006,236(1):89-94.
[195]Carter W B,Niu G,Ward M D,et al.Mechanisms of HER-2-induced endothelial cell retraction.Ann Surg Oncol,2007,14(10):2971-2978.
[196]Peinado H,Olmeda D,Cano A.Snail,Zeb and bHLH factors in tumour progression:an alliance against the epithelial phenotype?Nat Rev Cancer,2007,7(6):415-428.
[197]Jee Y S,Jang T J,Jung K H.Prostaglandin E(2)and interleukin-1beta reduce E-cadherin expression by enhancing snail expression in gastric cancer cells.J Korean Med Sci,2012,27(9):987-992.
[198]Hu Z,Liu X,Tang Z,et al.Possible regulatory role of Snail in NF-kappaB-mediated changes in E-cadherin in gastric cancer.Oncol Rep,2013,29(3):993-1000.
[199]Bachelder R E,Yoon S O,Franci C,et al.Glycogen synthase kinase-3is an endogenous inhibitor of Snail transcription:implications for the epithelial-mesenchymal transition.J Cell Biol,2005,168(1):29-33.
[200]De Craene B,van Roy F,Berx G.Unraveling signalling cascades for the Snail family of transcription factors.Cell Signal,2005,17(5):535-547.
[201]Zhou B P,Deng J,Xia W,et al.Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition.Nat Cell Biol,2004,6(10):931-940.
[202]Dominguez D,Montserrat-Sentis B,Virgos-Soler A,et al.Phosphorylation regulates the subcellular location and activity of the snail transcriptional repressor.Mol Cell Biol,2003,23(14):5078-5089.
[203]Macpherson M R,Molina P,Souchelnytskyi S,et al.Phosphorylation of serine 11and serine 92as new positive regulators of human Snail1function:potential involvement of casein kinase-2and the cAMP-activated kinase protein kinase A.Mol Biol Cell,2010,21(2):244-253.
[204]Yang Z,Rayala S,Nguyen D,et al.Pak1phosphorylation of snail,a master regulator of epithelial-tomesenchyme transition,modulates snail′s subcellular localization and functions.Cancer Res,2005,65 (8):3179-3184.
[205]Peinado H,Del C I L C,Olmeda D,et al.A molecular role for lysyl oxidase-like 2enzyme in snail regulation and tumor progression.EMBO J,2005,24(19):3446-3458.
[206]Vinas-Castells R,Beltran M,Valls G,et al.The hypoxia-controlled FBXL14ubiquitin ligase targets SNAIL1for proteasome degradation.J Biol Chem,2010,285(6):3794-3805.
[207]Grotegut S,von Schweinitz D,Christofori G,et al.Hepatocyte growth factor induces cell scattering through MAPK/Egr-1-mediated upregulation of Snail.EMBO J,2006,25(15):3534-3545.
[208]Morita T,Mayanagi T,Sobue K.Dual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodeling.J Cell Biol,2007,179(5):1027-1042.
[209]Sahlgren C,Gustafsson M V,Jin S,et al.Notch signaling mediates hypoxia-induced tumor cell migration and invasion.Proc Natl Acad Sci U S A,2008,105(17):6392-6397.
[210]Wu Y,Zhou B P.TNF-alpha/NF-kappaB/Snail pathway in cancer cell migration and invasion.Br J Cancer,2010,102(4):639-644.
[211]Julien S,Puig I,Caretti E,et al.Activation of NF-kappaB by Akt upregulates Snail expression and induces epithelium mesenchyme transition.Oncogene,2007,26(53):7445-7456.
[212]Mao Z,Ma X,Rong Y,et al.Connective tissue growth factor enhances the migration of gastric cancer through downregulation of E-cadherin via the NF-kappaB pathway.Cancer Sci,2011,102(1):104-110.
[213]Uchikado Y,Okumura H,Ishigami S,et al.Increased Slug and decreased E-cadherin expression is related to poor prognosis in patients with gastric cancer.Gastric Cancer,2011,14(1):41-49.
[214]Kang Y,Massague J.Epithelial-mesenchymal transitions:twist in development and metastasis.Cell,2004,118(3):277-279.
[215]Yang J,Mani S A,Donaher J L,et al.Twist,a master regulator of morphogenesis,plays an essential role in tumor metastasis.Cell,2004,117(7):927-939.
[216]Yang J,Weinberg R A.Epithelial-mesenchymal transition:at the crossroads of development and tumor metastasis.Dev Cell,2008,14(6):818-829.
[217]Elias M C,Tozer K R,Silber J R,et al.TWIST is expressed in human gliomas and promotes invasion.Neoplasia,2005,7(9):824-837.
[218]刘洪义,邢金,所剑.Twist基因沉默对人胃癌SGC7901细胞凋亡的影响.中国老年学杂志,2012,32 (16):826-828.
[219]刘爱东,庞久玲,郭红辉.基质金属蛋白酶-9在胃癌中的表达及意义.现代中西医结合杂志,2012,21 (13):1382-1383.
[220]Carneiro F,Oliveira C,Suriano G,et al.Molecular pathology of familial gastric cancer,with an emphasis on hereditary diffuse gastric cancer.J Clin Pathol,2008,61(1):25-30.
[221]Ghaffari S R,Rafati M,Sabokbar T,et al.A novel truncating mutation in the E-cadherin gene in the first Iranian family with hereditary diffuse gastric cancer.Eur J Surg Oncol,2010,36(6):559-562.
[222]Simoes-Correia J,Figueiredo J,Lopes R,et al.E-cadherin destabilization accounts for the pathogenicity of missense mutations in hereditary diffuse gastric cancer.PLoS One,2012,7(3):e33783.
[223]Yang Z,Zhang X,Gang H,et al.Up-regulation of gastric cancer cell invasion by Twist is accompanied by N-cadherin and fibronectin expression.Biochem Biophys Res Commun,2007,358(3):925-930.
[224]Kamikihara T,Ishigami S,Arigami T,et al.Clinical implications of N-cadherin expression in gastric cancer.Pathol Int,2012,62(3):161-166.
[225]Ma L,Teruya-Feldstein J,Weinberg R A.Tumour invasion and metastasis initiated by microRNA-10b in breast cancer.Nature,2007,449(7163):682-688.
[226]Park S M,Gaur A B,Lengyel E,et al.The miR-200family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1and ZEB2.Genes Dev,2008,22(7):894-907.
[227]Gregory P A,Bert A G,Paterson E L,et al.The miR-200family and miR-205regulate epithelial to mesenchymal transition by targeting ZEB1and SIP1.Nat Cell Biol,2008,10(5):593-601.
[228]Hurteau G J,Carlson J A,Spivack S D,et al.Overexpression of the microRNA hsa-miR-200cleads to reduced expression of transcription factor 8and increased expression of E-cadherin.Cancer Res,2007,67(17):7972-7976.
[229]Korpal M,Lee E S,Hu G,et al.The miR-200family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1and ZEB2.J Biol Chem,2008,283(22):14910-14914.
[230]谢乐,姜汉国.miRNA和肿瘤转移的研究进展.医学综述,2009,15:1505-1508.
[231]Resende C,Thiel A,Machado J C,et al.Gastric cancer:basic aspects.Helicobacter,2011,16(Suppl 1):38-44.