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第三节 科研工作概况
一、科研项目
1.2015年度中国神经内科医师获得的重大科研项目情况（总计：70项，按各医院所在地汉语拼音首字母排序）
（1）国家自然科学基金
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（2）其他基金
2.2015年度中国神经内科重大科研项目任务来源情况（单位：项）（图7-1）
图7-1 2015年度中国神经内科重大科研项目任务来源情况
3.2015年度中国神经内科获助科研项目经费情况（经费单位：万元）
图7-2 2015年度中国神经内科获助科研项目经费情况
二、获奖科研成果（总计：项）
2015年度中国神经内科医师获奖科研成果（按各医院所在地汉语拼音首字母排序）
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（注：只刊载国家级、省部级二等及以上奖励）
三、科研平台
2015年度中国神经内科省部级、市级重点科研平台（按各医院所在地汉语拼音首字母排序）
四、国际合作和交流
1.举办有重大影响的国际学术会议
2.获得国家科技部国际科技合作与交流专项、国家自然科学基金国际（地区）合作与交流重点项目等
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五、神经内科发表的SCI科研论文（IF≥3）
根据各医院上报资料进行分析，2015年度我国神经内科医师SCI文章发文情况：2015年中国神经内科医师发表SCI文章（IF≥3）共计419篇，其中论文（article、review）382篇，会议摘要（abstract）14篇，其他文献（letter、literature等文献类型）23篇。下图为本次年鉴所收集的2015年度中国神经内科医师发表SCI文章的影响因子情况。
图7-3 2015年度中国神经内科医师发表SCI文章的影响因子情况
2015年度中国神经内科医师发表SCI论文情况（按各医院所在地拼音首字母排序）
安徽省
1.张龙，汪凯（通信作者）．安徽医科大学第一附属医院．Trait-related decision making impairment in obsessivecompulsive disorder：evidence from decision making under ambiguity but not decision making under risk. Scienti fi c Reports.2015 Nov 25；5：17312.（IF：5.6）
2.田仰华，汪凯（通信作者）．安徽医科大学第一附属医院．A lateralized top-down network for visuospatial attention and neglect. Brain Imaging and Behavior.2015 Oct 27 ［Epub ahead of print］.（IF：4.6）
3.汪敬业，罗本燕（通信作者）．安徽医科大学第一附属医院．Probenecid protects against cerebral ischemia reperfusion injury by inhibiting lysosomal and in fl ammatory damage in rats.Neuroscience.2015 Aug 20；301：168-77.（IF：3.6）
4.汪凯（通信作者）．安徽医科大学第一附属医院．Clozapine improves the orienting of attention in schizophrenia. Schizophr Res.2015 Oct；168（1-2）：285-91.（IF：3.9）
5.张龙，汪凯（通信作者）．安徽医科大学第一附属医院．Dissociation of decision making under ambiguity and decision making under risk：a neurocognitive endophenotype candidate for obsessive-compulsive disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry.2015 Mar 3；57：60-8.（IF：3.7）
6.张龙，汪凯（通信作者）．安徽医科大学第一附属医院．Similarities and Differences in Decision-Making Impairments between Autism Spectrum Disorder and Schizophrenia. Front Behav Neurosci.2015；9：259.（IF：3.3）
7.席春华，汪凯（通信作者）．安徽医科大学第一附属医院．Theory of mind and decision-making processes are impaired in Parkinson’s disease.Behav Brain Res. 2015 Feb 15；279：226-33.（IF：3.0）
8.余永强，孙中武（通信作者）．安徽医科大学第一附属医院．Small-World Brain Network and Dynamic Functional Distribution in Patients with Subcortical Vascular Cognitive Impairment. PLoS One.2015，10（7）：e0131893.（IF：3.2）
9.李良勇，王玉（通信作者）．安徽医科大学第一附属医院．Successful Splenectomy for Hypersplenism in Wilson’s Disease：A Single Center Experience from China. PLoS One.2015，24；10（4）：e0124569.（IF：3.2）
10.张龙，汪凯（通信作者）．安徽医科大学第一附属医院．Trait Anxiety Has Effect on Decision Making under Ambiguity but Not Decision Making under Risk. PLoS One.2015；10（5）：e0127189.（IF：3.2）
11.操瑞花，汪凯（通信作者）．安徽医科大学第一附属医院．Exploring Biological Motion Processing in Parkinson’s Disease Using Temporal Dilation. PLoS One. 2015 Sep 18；10（9）201.（IF：3.2）
12.袁莉莉，汪凯（通信作者）．安徽医科大学第一附属医院．Decision-Making in Patients with Hyperthyroidism：A Neuropsychological Study. PLoS One. June 19，2015.（IF：3.2）
北京市
1.唐毅．首都医科大学宣武医院．Mercury Poisoning Presenting as Sporadic Creutzfeldt-Jakob Disease. Annals of Internal Medicine.2015；162（6）：462-463.（IF=16.1）
2.贾建平．首都医科大学宣武医院．Diagnosis and treatment of dementia in neurology outpatient departments of general hospitals in China .Alzheimers Dement.2015，6：1892-.（IF=12.407）
3.贾建平．首都医科大学宣武医院．The effects of DL-3-n-butylphthalide in patients with vascular cognitive impairment without dementia caused by subcortical ischemic small vessel disease：A multicentre，randomized，double-blind，placebo-controlled trial. Alzheimers Dement.2015，4：10-15.（IF=12.407）
4.刘佳．首都医科大学宣武医院．Peroxisome proliferator-activated receptor gamma agonists for preventing recurrent stroke and other vascular events in patients with stroke or transient ischaemic attack. Cochrane Database Syst Rev.2015，10.（IF=6.032）
5.刘佳．首都医科大学宣武医院．Topiramate monotherapy for juvenile myoclonic epilepsy. Cochrane Database Syst Rev.2015，12：CD010008.（IF=6.032）
6.刘佳．首都医科大学宣武医院．Baclofen for alcohol withdraw. Cochrane Database Syst Rev.2015，4.（IF=5.939）
7.刘佳．首都医科大学宣武医院．Pharmacological treatment for pain in Guillain-Barré syndrome. Cochrane Database Syst Rev.2015，4.（IF=5.939）
8.亓爱芹．首都医科大学宣武医院．Thioredoxin is a novel diagnostic and prognostic marker in patients with ischemic stroke. Free Radical Biology and Medicine.2015，80：129-135.（IF=5.71）
9.孟然．首都医科大学宣武医院．Ischemic Conditioning Is Safe and Effective fou Octo-and Nonagenarians in Stroke Prevention and Treatment.Neurotherapeutics.2015，.（IF=5.054）
10.刘佳．首都医科大学宣武医院．Frontotemporal lobar degeneration with accumulation of argyrophilic grains and Lewy bodies：a clinicopathological Report.Journal of Alzheimer disease.2015，48：55-58.（IF=4.151）
11.王欠欠．首都医科大学宣武医院．A novel AβPP M722K mutation affects Aβsecretion and tau phosphorylation and may cause early-onset. Journal of Alzheimer’ s disease.2015，47（1）：157- 165.（IF=4.151）
12.秦伟．首都医科大学宣武医院．Elevated plasma angiogenesis factors in Alzheimer’s disease.J Alzheimers Dis.2015，45：245-252.（IF=4.151）
13.李景云 林华．首都医科大学宣武医院．Association study of functional polymorphisms in serrotonin transporter gene with temporal lobe epilepsy in Han Chinese population. European journal of neurology.2015，19：351-353.（IF=4.055）
14.孙宇．首都医科大学宣武医院．Biochemical and Neuroimaging Studies in Subjective Cognitive Decline. CNS Neuroscience & Therapeutics.2015.（IF=3.931）
15.李玉霞．首都医科大学宣武医院．Abnormal Resting-State Functional Connectivity Strength in Mild Cognitive Impairment and Its Convers. Neural Plasticity.2015，10.（IF=3.582）
16.邸丽，陈海．首都医科大学宣武医院．Atypical familial amyotrophic lateral sclerosis with initial symptoms of pain or tremor in a Chinese family harboring VAPBP56S mutation.J Neurol. 2015，14.（IF=3.377）
17.王宪玲．首都医科大学宣武医院．Hypervalinemia and hyperleucine-isoleucinemia caused by mutations in the branched-chain-amino-acid aminotransferase gene. J Inherit Metab Dis.2015，38：855-861.（IF=3.365）
18.宋海庆．首都医科大学宣武医院．APOE Effects on Default Mode Network in Chinese Cognitive Normal Elderly：Relationship with Clinical Cognitive Performance. PLoS One.2015，07：1-11.（IF=3.234）
19.马青峰．首都医科大学宣武医院．Intravenous versus Intra-Arterial Thrombolysis in Ischemic Stroke：A Systematic Review and Meta-Analysis. PLoS One.2015，8：1-13.（IF=3.234）
20.黄镪，马青峰．首都医科大学宣武医院．Factors Associated with In-Hospital Delay in Intravenous Thrombolysis for Acute Ischemic Stroke：Lessons from China. PLoS One.2015，17：1-9.（IF=3.234）
21.刘瑞琴．首都医科大学宣武医院．Characterization of the interactions between beta-amyloid peptide and the membranes of human SK-N-SH cells. FEBS Lett.2015，589：1929-1934.（IF=3.169）
22.刘春燕．首都医科大学宣武医院．Mapping intrinsic functional brain changes and repetitive transcranial magnetic stimulation neuromodulation in idiopathic restless legs syndrome：a resting-state functional magnetic resonance imaging study. Sleep Medicine.2015，16：785-791.（IF=3.154）
23.何及，Brown-MA（通讯作者）．北京大学第三医院/澳大利亚昆士兰大学．Amyotrophic lateral sclerosis genetic studies from genome-wide association mapping to genome sequencing. Neuroscientist. 2015；21：599-615.（IF：6.837）
24.陈璐，樊东升（通讯作者）．北京大学第三医院．Natural history and clinical features of sporadic amytrophic lateral scalerosis in China.J Neurol Neurosurg Psychiatry.2015；86：1075-81.（IF：6.807）
25.何及，Brown-MA，樊东升（通讯作者）．北京大学第三医院/澳大利亚昆士兰大学．C9orf72 hexanucleotide repeat expansions in Chinese sporadic amyotrophic lateral sclerosis. Neurobiol Aging. 2015；36：2660e1-8.（IF：5.013）
26.田小生，崔德华（通讯作者）．北京大学第三医院/北京大学神经科学研究所．Surgical stress induces brainderived neurotrophic factor reduction and postoperative cognitive dysfunction via glucocorticoid receptor phosphorylation in aged mice. CNS Neuroscience & Therapeutics.2015；21：398-409.（IF：3.931）
27.杨欢，崔德华（通讯作者）．北京大学第三医院/北京大学神经科学研究所．Lipoprotein lipase deficiency leads to a-synuclein aggregation and ubiquitin C-terminal dydorlase L1 reduction. Neuroscience.2015；290：1-10.（IF：3.357）
28.刘艳，王振福（通讯作者）．中国人民解放军总医院老年神经内科．Tai chi for schizophrenia. Cochrane database of systematic reviews.2015；Issue1.（IF：6.032）
29.谭纪萍，王鲁宁（通讯作者）．中国人民解放军总医院老年神经内科．Optimal cutoff scores for dementia andmild cognitive impairment of the montreal cognitive assessment among elderly and oldest-old Chinese population. J Alzheimers Dis.2015；43：1403-1412.（IF：4.151）
30.刘佳，朱明伟，王鲁宁（通讯作者）．中国人民解放军总医院老年神经内科．Frontotemporal lobar degeneration with accumulation of argyrophilic grains and Lewy bodies：a clinicopathological report. J Alzheimers Dis.2015；48：55-58.（IF：4.151）
31.王盼，张熙（通讯作者）．中国人民解放军总医院老年神经内科．Aberrant intra- and inter-networkconnectivity architectures in Alzheimer’s disease and mild cognitive impairment. Scientific Reports.2015；5：14824.（IF：5.578）
32.Ting Gao，JinHao Lyu，JiaTang Zhang，et al.中国人民解放军总医院神经内科．Diffusion-weighted MRI fi ndings and clinical correlations in sporadic Creutzfeldt-Jakob disease. J Neurol.2015；262：1440-1446.（IF：3.377）
33.Zhiye Chen，Xin Lou，Mengqi Liu，et al.中国人民解放军总医院神经内科．Assessment of Optic Nerve Impairment in Patients with Neuromyelitis Optica by MR Diffusion Tensor Imaging. PLOS ONE.2015 May；10（5）：e0126574.（IF：3.234）
34.Rong-Tai Cui，Sheng-Yuan Yu，Xu-Sheng Huang，et al.中国人民解放军总医院神经内科．Incidence and risk factors of pleural effusions in patients with POEMS syndrome. Hematol Oncol. 2015；33：80-84；.（IF：3.234）
35.Hu R，Cui F.中国人民解放军总医院神经内科．Long- and Short-Term Health Effects of Pesticide Exposure A Cohort Study from China. PLoS One.2015 Jun 4；10（6）：e0128766.（IF：3.234）
36.Min Chen，Shengyuan Yu.中国人民解放军总医院神经内科．Tumor Necrosis Factor（TNF）-308G>A，Nitric Oxide Synthase 3（NOS3）+894G>T Polymorphisms and Migraine Risk：A Meta-Analysis. PLoS One.2015 Jun 22；10（6）：e0129372.（IF：3.234）
37.Zhao Dong，Shengyuan Yu.中国人民解放军总医院神经内科．Medication- overuse headache in China：Clinical pro fi le，and an evaluation of the ICHD-3 beta diagnostic criteria. Cephalalgia.2015，Vol 35（8）644-651.（IF：4.891）
38.Li Li，Shengyuan Yu.中国人民解放军总医院神经内科．Impact of ESR1 Gene Polymorphisms on Migraine Susceptibility：A Meta-Analysis. Medicine. 2015Sep；94（35）：e0976.（IF：5.723）
39.Feng qiu.中国人民解放军海军总医院．Percentages of CD4+CD161+ and CD4-CD8-CD161+ T cells in the synovial fluid are correlated with disease activity in rheumatoid arthritis. Mediators of Inflammation.2015（2015），Article ID 563713，7 pages.（IF：3.236）
40.Feng qiu.中国人民解放军海军总医院．Construction，expression and characterization of an immunotoxin of EpCAM. Mediators of In fl ammation.2015（2015），Article ID 460264，11 pages.（IF：3.236）
重庆市
1.Zhou X，Xie P（通讯作者）．重庆医科大学附属第一医院．Comparative efficacy and acceptability of psychotherapies for depression in children and adolescents：a systematic review and network meta-analysis. World Psychiatry.2015；14（2）：207-22.（IF：14.225）
2.Li Q，Xie P（通讯作者）．重庆医科大学附属第一医院．Blend Sign on Computed Tomography Novel and Reliable Predictor for Early Hematoma Growth in Patients With Intracerebral Hemorrhage. Stroke. 2015 Aug；46（8）：2119-23.（IF：5.723）
3.Xu F，Xie P（通讯作者）．重庆医科大学附属第一医院．Macaques Exhibit a Naturally-Occurring Depression Similar to Humans. Scienti fi c Reports.2015；5：9220.（IF：5.578）
4.Luo QH，Xie P（通讯作者）．重庆医科大学附属第一医院．Frequency Dependant Topological Alterations of Intrinsic Functional Connectome in Major Depressive Disorder. Scienti fi c Reports.2015；5：9710.（IF：5.578）
5.Li Q，Xie P（通讯作者）．重庆医科大学附属第一医院．Intraventricular Hemorrhage and Early Hematoma Expansion in Patients with Intracerebral Hemorrhage. Scienti fi c Reports.2015 Jun 18；5：11357.（IF：5.578）
6.Cheng P，Xie P（通讯作者）．重庆医科大学附属第一医院．BMI Affects the Relationship between Long Chain N-3 Polyunsaturated Fatty Acid Intake and Stroke Risk：a Meta-Analysis. Scienti fi c Reports. 2015 Sep 15；5：14161.（IF：5.578）
7.Zhang Y，Xie P（通讯作者）．重庆医科大学附属第一医院．Free Language Selection in the Bilingual Brain：An ER-fMRI Study. Scienti fi c Reports. 2015 Jul 16；5：11704.（IF：5.578）
8.Liu B，Xie P（通讯作者）．重庆医科大学附属第一医院．A Highly Similar Mathematical Model for Cerebral Blood Flow Velocity in Geriatric Patients with Suspected Cerebrovascular Disease. Scienti fi c Reports.2015 Oct 26；5：15771.（IF：5.578）
9.Zhou X，Xie P（通讯作者）．重庆医科大学附属第一医院．Comparative Efficacy，Acceptability，and Tolerability of Augmentation Agents in Treatment-Resistant Depression：Systematic Review and Network Meta-Analysis. J Clin Psychiatry. 2015 Apr；76（4）：e487-98.（IF：5.498）
10.Zhou X，Xie P（通讯作者）．重庆医科大学附属第一医院．Ef fi cacy and tolerability of antidepressants in the treatment of adolescents and young adults with depression and substance use disorders：a systematic review and meta-analysis. Addiction.2015 Jan；110（1）：38-48.（IF：4.738）
11.Liu X，Xie P（通讯作者），Xu G.重庆医科大学附属第一医院．Discovery and validation of plasma biomarkers for major depressive disorder classification based on liquidchromatography-mass spectrometry. Journal of Proteome Research. 2015 May 1；14（5）：2322-30.（IF：4.245）
12.Chen JJ，Xie P（通讯作者）．重庆医科大学附属第一医院．Divergent Urinary Metabolic Phenotypes between Major Depressive Disorder and Bipolar Disorder Identi fi ed by a Combined GC-MS and NMR. Spectroscopic Metabonomic Approach. 2015 Aug 7；14（8）：3382-9.（IF：4.245）
13.Zhou X，Xie P（通讯作者）．重庆医科大学附属第一医院．Atypical Antipsychotic Augmentation for Treatment-Resistant Depression：A Systematic Review and Network Meta-Analysis. The International Journal of Neuropsychopharmacology. 2015；Accepted.（IF：4.009）
14.Zhou J，Xie P（通讯作者）．重庆医科大学附属第一医院．Quantitative proteomic analysis reveals molecular adaptations in the hippocampal synaptic active zone of chronic mild stress-unsusceptible rats. International Journal of Neuropsychopharmacology.2015 Sep 12.pii：pyv100.（IF：4.009）
15.Liu ML，Xie P（通讯作者）．重庆医科大学附属第一医院．Severe disturbance of glucose metabolism in peripheral blood mononuclear cells of schizophrenia patients：a targeted metabolomic study. Journal Of Translational Medicine. 2015；13：226.（IF：3.93）
16.Cheng PF，Xie P（通讯作者）．重庆医科大学附属第一医院．Do soy iso fl avones improve cognitive function in postmenopausal women A meta-analysis. Menopause.2015 Feb；22（2）：198-206.（IF：3.361）
17.Han X，Xie P（通讯作者）．重庆医科大学附属第一医院．iTRAQ-Based Quantitative Analysis of Hippocampal Postsynaptic Density- Associated Proteins in a Rat Chronic Mild Stress Model of Depression. Neuroscience.2015；298：220-292.（IF：3.357）
18.Liu X，Xie P（通讯作者）．重庆医科大学附属第一医院．Persistent Human Borna Disease Virus Infection Modifies the Acetylome of Human Oligodendroglia Cells towards Higher Energy and Transporter Levels. Virology.2015；485：58-78.（IF：3.321）
19.Chen J，XieP.重庆医科大学附属第一医院．Comparative proteomic analysis of plasma from bipolar depression and depressive disorder：identification ofproteins associated with immune regulatory. Protein Cell. 2015 Oct 16.（IF：3.247）
20.Bo Liu，Peng Xie.重庆医科大学附属第一医院．A Non-Invasive Method to Assess Cerebral Perfusion Pressure in Geriatric Patients with Suspected Cerebrovascular Disease. PLoS One.2015；10（3）：e0120146.（IF：3.234）
21.Liang Fang，Zhou Chanjuan.重庆医科大学附属第一医院．The C825T Polymorphism of the G-Proteinβ3 Gene as a Risk Factor for Depression：a Meta-Analysis. PLOS ONE.2015；DOI：10.1371/journal.pone.0132274.（IF：3.234）
22.Zhang S，XieP.重庆医科大学附属第一医院．Behavioral characterization of CD36 knockout mice with SHIRPA primary screen. Behav Brain Res. 2015 Nov 25；299：90-96.（IF：3.028）
23.陈国俊．重庆医科大学附属第一医院．Modulation of AMPA receptor mediated current by nicotinic acetylcholine receptor in layer I neurons of rat prefrontal cortex. Sci Rep.2015 Sep 15；5：14099.（IF：5.578）
24.秦新月．重庆医科大学附属第一医院．Overexpression of Fibulin-5 Attenuates Ischemia/ Reperfusion Injury After Middle Cerebral Artery Occlusion in Rats. Mol Neurobiol.DOI 10.1007/s12035-015-9222-2.（IF：5.286）
25.王学峰．重庆医科大学附属第一医院．5-HT6 Receptor Recruitment of mTOR Modulates Seizure Activity in Epilepsy．Mol Neurobiol.2015 Jun；51（3）：1292-9.（IF：5.286）
26.李琦．重庆医科大学附属第一医院．Intraventricular Hemorrhage and Early Hematoma Expansion in Patients with Intracerebral Hemorrhage. Sci Rep.2015 Jun 18；5：11357.（IF：5.078）
27.王学峰．重庆医科大学附属第一医院．Increased expression of receptor for activated C kinase 1 in temporal lobe epilepsy. J Neurochem.2015 Apr；133（1）：134-43.（IF：4.244）
28.余刚．重庆医科大学附属第一医院．Histone acetylation modi fi ers in the pathogenesis of Alzheimer’s disease. Front Cell Neurosci.2015 Jun 16；9：226.（IF：4.175）
29.周冀英．重庆医科大学附属第一医院．Metabolic syndrome in female migraine patients is associated with medication overuse headache：a clinic-based study in China.Eur J Neurol.2015 Aug；22（8）：1228-34.（IF：4.055）
30.承欧梅．重庆医科大学附属第一医院．Alterations in the limbic/paralimbic cortices of Parkinson’s disease patients with hyposmia under resting-state functional MRI by regional homogeneity and functional connectivity analysis. Parkinsonism Relat Disord.2015 Jul；21（7）：698-703.（IF：3.972）
31.王学峰．重庆医科大学附属第一医院．ENT1 Inhibition Attenuates Epileptic Seizure Severity Via Regulation of Glutamatergic Neurotransmission. Neuromolecular Med.2015 Mar；17（1）：1-11.（IF：3.885）
32.王学峰．重庆医科大学附属第一医院．The role and potential mechanism of resveratrol in the prevention and control of epilepsy. Future Med Chem.2015 Oct；7（15）：2005-18.（IF：3.744）
33.杨琴．重庆医科大学附属第一医院．Sonic Hedgehog Signaling Mediates Resveratrol to Increase Proliferation of Neural Stem Cells After Oxygen-Glucose Deprivation/Reoxygenation Injury in Vitro. Cell Physiol Biochem.2015 Apr；35（5）：2019-32.（IF：3.55）
34.王学峰．重庆医科大学附属第一医院．The ef fi cacy and safety of brivaracetam at different doses for partialonset epilepsy：a meta-analysis of placebo-controlled studies. Expert Opin Pharmacother.2015 Jul；16（12）：1755-67.（IF：3.534）
35.刘光维．重庆医科大学附属第一医院．Risk factors for lung infection in stroke patients：a meta-analysis of observational studies. Expert Rev Anti Infect Ther.2015 Oct；13（10）：1289-98.（IF：3.461）
36.王学峰．重庆医科大学附属第一医院．Effects of JIP3 on epileptic seizures：Evidence from temporal lobe epilepsy patients，kainic-induced acute seizures and pentylenetetrazole-induced kindled seizures. Neuroscience.2015 Aug 6；300：314-24.（IF：3.357）
37.王学峰．重庆医科大学附属第一医院．Minocycline inhibits brain inflammation and attenuates spontaneous recurrent seizures following pilocarpine-induced status epilepticus. Neuroscience.2015 Feb 26；287：144-56.（IF：3.327）
38.王学峰．重庆医科大学附属第一医院．Inhibition of the small GTPase Cdc42 in regulation of epileptic-seizure in rats. Neuroscience.2015 Mar 19；289：381-91.（IF：3.327）
39.秦新月．重庆医科大学附属第一医院．Subtypes and Prognosis of Guillain-Barre Syndrome in Southwest China. PLoS One.2015 Jul 22；10（7）：e0133520.（IF：3.234）
40.王学峰．重庆医科大学附属第一医院．The Brain Activity in Brodmann Area 17：A Potential Bio-Marker to Predict Patient Responses to Antiepileptic Drugs. PLoS One.2015 Oct 6；10（10）：e0139819.（IF：3.234）
41.刘光维．重庆医科大学附属第一医院．Characteristics and prognosis of pulmonary infection in patients with neurologic disease and hypoproteinemia. Expert Rev Anti Infect Ther.2015 Apr；13（4）：521-6.（IF：3.063）
42.陈国俊．重庆医科大学附属第一医院．Alzheimer disease and cancer risk：a meta-analysis. J Cancer Res Clin Oncol.2015 Mar；141（3）：485-94.（IF：3.009）
43.刘彬，李长清．重庆医科大学附属第二医院．Gadd45b Mediates Axonal Plasticity and Subsequent Functional Recovery After Experimental Stroke in Rats. Molecular Neurobiology.2015（52）：1245-1256.（IF：5.286）
44.刘彬，李长清．重庆医科大学附属第二医院．Gadd45b is a Novel Mediator of Neuronal Apoptosis in Ischemic Stroke .Innternational Journal of Biological Sciences.2015；11（3）：353-360.（IF：4.372）
45.何国倩，李长清．重庆医科大学附属第二医院．Huwe1 interacts with Gadd45b under oxygen-glucose deprivation and reperfusion injury in primary Rat cortical neuronal cells.Molecular Brain.2015，8：88.（IF：4.902）
46.蒋莹，李长清．重庆医科大学附属第二医院．miR-210 mediates vagus nerve stimulation-induced antioxidant stress and anti-apoptosis reactions following cerebral ischemia/reperfusion injury in rats. Journal of Neurochemistry. 2015；134（1）：173-81.（IF：4.281）
47.付洁，陈阳美．重庆医科大学附属第二医院．The efficacy and safety of 5 mg/d Vortioxetine compared to placebo for major depressive disorder：A meta-analysis. Psychopharmacology. 2015；232：7-16.（IF：3.875）
48.刘波，李志伟（通讯作者）．重庆医科大学附属永川医院．A Non-Invasive Method to Assess Cerebral Perfusion Pressure in Geriatric Patients with Suspected Cerebrovascular Disease. PLoS One.2015 Mar 19；10（3）：e0120146.（IF：3.234）
49.杨曌（第一作者3人）．重庆医科大学附属永川医院．Toll-like receptor-4-mediated autophagy contributes to microglial activation and in fl ammatory injury in mouse models of intracerebral haemorrhage. Neuropathol Appl Neurobiol.2015 Jun；41（4）：e95-106.（IF：3.927）
50.杨曌（通讯作者）．重庆医科大学附属永川医院．A novel nanoparticle containing nueritin peptide with grp170 induce a CTL response to inhibit tumor growth. J Neurooncol.2015 Oct；125（1）：23-32.（IF：3.07）
51.周锐，周华东（通讯作者）．大坪医院神经内科．Carotid and vertebral arterial variations in Alzheimer’s disease. Curr Alzheimer Res.2015；12（4）：368-76.（IF：3.796）
52.李工博，周华东（通讯作者）．大坪医院神经内科．Common Pesticide Dichlorodiphenyltrichloroethane（DDT），Increases Amyloid-βLevels by Impairing the Function of ABCA1 and IDE：Implication for Alzheimer’s Disease. J Alzheimers Dis.2015；46（1）：109-22.（IF：3.612）
53.曾凡，王延江（通讯作者）．大坪医院神经内科．Genetic Association Between APP，ADAM10 Gene Polymorphism，and Sporadic Alzheimer’s Disease in the Chinese Population. Neurotox Res.2015 Apr；27（3）：284-91.（IF：3.151）
54.刘雨辉，王延江（通讯作者）．大坪医院神经内科．Clearance of amyloid-beta in Alzheimer’s disease：shifting the action site from center to periphery. Mol Neurobiol.2015 Feb；51（1）：1-7.（IF：5.286）
55.刘雨辉，王延江（通讯作者）．大坪医院神经内科．Serum Aβis Predictive for Short-Term Neurological De fi cits After Acute Ischemic Stroke . Neurotox Res.2015 Apr；27（3）：292-9.（IF：3.151）
56.刘雨辉，王延江（通讯作者）．大坪医院神经内科．An N-terminal antibody promotes the transformation of amyloid fibrils into oligomers and enhances the neurotoxicity of amyloid-beta：the dust-raising effect. J Neuroin fl ammation.2015 Aug 28；12（1）：153.（IF：5.408）
57.刘雨辉，王延江（通讯作者）．大坪医院神经内科．Association Between Serum Amyloid-Beta and Renal Functions：Implications for Roles of Kidney in Amyloid-Beta Clearance. Mol Neurobiol.2015 Aug；52（1）：115-9.（IF：5.137）
58.刘雨辉，王延江（通讯作者）．大坪医院神经内科．Associations Between ApoEε4 Carrier Status and Serum BDNF Levels-New Insights into the Molecular Mechanism of ApoEε4 Actions in Alzheimer’s Disease. Mol Neurobiol.2015 Jun；51（3）：1271-7.（IF：5.137）
59.卜先乐，王延江（通讯作者）．大坪医院神经内科．Serum amyloid-beta levels are increased in patients with obstructive sleep apnea syndrome. Sci Rep.2015 Sep 9；5：13917.（IF：5.578）
60.卜先乐，王延江（通讯作者）．大坪医院神经内科．The association between infectious burden and Parkinson’s disease：A case-control study. Parkinsonism Relat Disord.2015 Aug；21（8）：877-81.（3.972）
61.卜先乐，王延江（通讯作者）．大坪医院神经内科．Serum Amyloid-Beta Levels are Increased in Patients with Chronic Obstructive Pulmonary Disease. Neurotox Res.2015 Nov；28（4）：346-51.（IF：3.538）
62.卜先乐，王延江（通讯作者）．大坪医院神经内科．A study on the association between infectious burden and Alzheimer’s disease. Eur J Neurol.2015 Dec；22（12）：1519-25.（IF：4.055）
63.姚秀卿，王延江（通讯作者）．大坪医院神经内科．p75NTR ectodomain is a physiological neuroprotective molecule against amyloid-beta toxicity in the brain of Alzheimer’s disease. Mol Psychiatry.2015 Nov；20（11）：1301-10.（IF：14.496）
64.矫树生，王延江（通讯作者）．大坪医院神经内科．Edaravone alleviates Alzheimer’s disease-type pathologies and cognitive de fi cits. Proc Natl Acad Sci U S A.2015 Apr 21；112（16）：5225-30.（IF：9.674）
65.矫树生，王延江（通讯作者）．大坪医院神经内科．Differential levels of p75NTR ectodomain in CSF and blood in patients with Alzheimer’s disease：a novel diagnostic marker. Transl Psychiatry.2015 Oct 6；5：e650.（IF：5.62）
66.向阳，王延江（通讯作者）．大坪医院神经内科．Physiological amyloid-beta clearance in the periphery and its therapeutic potential for Alzheimer’s disease .Acta Neuropathol.2015 Oct；130（4）：487-99.（IF：10.762）
67.张明杰，张莉莉（通讯作者）．大坪医院神经内科．The role of TRPV1 in improving VSMC function and attenuating hypertension. Prog Biophys Mol Biol.2015 Mar；117（2-3）：212-6.（IF：3.377）
68.郭露，李敬诚（通讯作者）．大坪医院神经内科．IRAK1 mediates TLR4-induced ABCA1 downregulation and lipid accumulation in VSMCs. Cell Death Dis.2015 Oct 29；6：e1949.（IF：5.014）
69.叶园园，蒋晓江（通讯作者）．大坪医院神经内科．Internet-Based Cognitive Behavioral Therapy for Insomnia（ICBT-i）Improves Comorbid Anxiety and Depression-A Meta-Analysis of Randomized Controlled Trials. PLoS One.2015 Nov 18；10（11）：e0142258.（IF：3.234）
70.王鹏飞．Department of Neurology，Xinqiao Hospital，The Third Military Medical University. Function and mechanism of tolllike receptors in cerebral ischemic tolerance：from preconditioning to treatment. J Neuroin fl ammation. 2015 Apr 28；12：80.（IF：5.408）
71.冉鸿．Department of Neurology，Xinqiao Hospital，The Third Military Medical University. Critical contribution of adenosine A2A receptors in bone marrowderived cells to white matter lesions induced by chronic cerebral hypoperfusion . J Neuropathol Exp Neurol. 2015 Apr；74（4）：30518.（IF：3.797）
72.后显华．Department of Neurology，Xinqiao Hospital，The Third Military Medical University.Department of Neurology，Xinqiao Hospital，The Third Military Medical University. Neuroscience. 2015 Jun 25；297：11826.（IF：3.357）
73.丁鑫．Department of Neurology，Xinqiao Hospital，The Third Military Medical University. Speci fi c locations within the white matter and cortex are involved in the cognitive impairments associated with periventricular white matter lesions（PWMLs）． Behav Brain Res.，Epub 2015 Apr 18（2015 Aug 1；289：918）．（IF：3.028）
74.段炜．Department of Neurology，Xinqiao Hospital，The Third Military Medical University. Novel Insights into NeuN：from Neuronal Marker to Splicing Regulator. Mol Neurobiol. 2015 Feb 14.（IF：5.286）
75.郑健．Department of Neurology，Xinqiao Hospital，The Third Military Medical University. Critical contribution of adenosine A2A receptors in bone marrow derived cells to white matter lesions induced by chronic cerebral hypoperfusion . J Neuropathol Exp Neurol. 2015 Apr；74（4）：30518.（IF：4.372）
福建省
1.Jian Zhang，Jing Zhang.福建医科大学附属第一医院．Tripchlorolide ameliorates experimental autoimmune encephalomyelitis by down-regulating ERK1/2-NF-кB and JAK/STAT signaling pathways.J Neurochemistry.2015；133，104-112.（IF：4.281）
2.Liu DS，Zhang J，et al.福建医科大学附属第一医院．APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice. Mol Neurodegener.2015 Mar 5；10（1）：7.（IF：6.563）
3.Zeng Y，Zhu Y，et al.福建医科大学附属第一医院．Tripchlorolide improves cognitive deficits by reducing amyloid β and upregulating synapse-related proteins in a transgenic model of Alzheimer’s. J Neurochem.2015 Apr；133（1）：38-52.（IF：4.281）
4.Bing Ye，Jing Zhang，et al.福建医科大学附属第一医院．Dual Pathways Mediate b-Amyloid Stimulated Glutathione Release from Astrocytes. Glia.2015 Jul 21.（IF：6.031）
5.Lin L，Zhang Y，et al.福建医科大学附属第一医院．IL-10 Protects Neurites in Oxygen-Glucose-Deprived Cortical Neurons through the PI3K/Akt Pathway. PLoS One 2015.10（9）：e013695956.（IF：3.234）
6.Ye Q（通讯作者），Chen XC.福建医科大学附属第一医院．Overexpression of PGC-1αInfluences Mitochondrial Signal Transduction of Dopaminergic Neurons. Mol Neurobiol.2015 Jul.（IF：5.137）
7.Lin N，Chen XC（通讯作者）．福建医科大学附属第一医院．Tripchlorolide Attenuatesβ-amyloid Generation via Suppressing PPARγ-Regulated BACE1 Activity in N2a/APP695 Cells. Molecular Neurobiology.2015，Nov.（IF：5.137）
8.Lanyan Lin，Chen XC（通讯作者）．福建医科大学附属第一医院．Early life stress impairs the spatial learning and memory of mid-aged ApoE4-TR mice. Mol Neurodegener. 2015（Accepted）．（IF：6.563）
9.Jia J，Zhang J，et al.福建医科大学附属第一医院．The effects of DL-3-n-butylphthalide in patients with vascular cognitive impairment without dementia caused by subcortical ischemic small vessel disease：A multicentre，randomized，double-blind，placebo-controlled trial. Alzheimers Dement.2015 Jun 15.（IF：12.407）
广东省
1.Chen H，Zeng J（通讯作者）．中山大学附属第一医院．Anterior cerebral artery dissection diagnosed using high-resolution MRI. Neurology. 2015，85（5）：481.（IF：8.286）
2.Zhang Y，Zhang C（通讯作者）．中山大学附属第一医院．Long-term engraftment of myogenic progenitors from adipose-derived stem cells and muscle regeneration in dystrophic mice. Hum Mol Genet. 2015，24（21）：6029-6040.（IF：6.393）
3.Chen Y，Zeng J（通讯作者）．中山大学附属第一医院．Stroke Event Rates and the Optimal Antithrombotic Choice of Patients With Paroxysmal Atrial Fibrillation：A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Medicine（ Baltimore）．2015，94（52）：e2364.（IF：5.723）
4.Chen X，Pei Z（通讯作者），Huang R（通讯作者）．中山大学附属第一医院．Inhibition of immunoproteasome reduces infarction volume and attenuates in fl ammatory reaction in a rat model of ischemic Stroke . Cell Death Dis.2015，29，（6）：e1626.（IF：5.014）
5.Gang Liu，Jinsheng Zeng（通讯作者）．中山大学附属第一医院．Increased spontaneous neuronal activity in structurally damaged cortex is correlated with early motor recovery in patients with subcortical infarction Eur. J Neurol.2015，22：1540-1547.（IF：4.055）
6.Hongliang Li，Liemin Zhou（通讯作者），Min Huang（通讯作者）．中山大学附属第一医院．Association of LEPR and ANKK1 Gene Polymorphisms with Weight Gain in Epilepsy Patients Receiving Valproic Acid. International Journal of Neuropsychopharmacology. 2015，1-7.（IF：4.009）
7.Linfang Lan，Yuhua Fan（通讯作者）．中山大学附属第一医院．Peroxisome proliferator-activated receptorγagnonist pioglitazone ameliorates white matter lesion and cognitive impairment in hypertensive rats. CNS Neuroscience and Therapeutics.2015，21（5）：410-416.（IF：3.931）
8.Wang Q，Li L（通讯作者）．中山大学附属第一医院．SIRT3 protects cells from hypoxia via PGC1-α and MnSOD pathways. Neuroscience. 2015，286：109-121.（IF：3.357）
9.Di W，Zhang Aw（通讯作者），Fang Yn（通讯作者）．中山大学附属第一医院．Pregabalin alleviates the nitroglycerin-induced hyperalgesia in rats. Neuroscience. 2015，284：11-17.（IF：3.357）
10.Jiqing C，Cheng Z（通讯作者）．中山大学附属第一医院．BMP4 inhibits myogenic differentiation of bone marrow-derived mesenchymal stromal cells in mdx mice. Cytotherapy. 2015，17（9）：1213-1219.（IF：3.293）
11.Guanzhong Ni，Liemin Zhou（通讯作者）．中山大学附属第一医院．Effects of Antiepileptic Drug Monotherapy on One-Carbon Metabolism and DNA Methylation in Patients with Epilepsy. PLOS ONE（OPEN ACCESS）．2015，27：1-10.（IF：3.234）
12.Ying Yang，Jinsheng Zeng（通讯作者）．中山大学附属第一医院．Risk factor differences between type 2 diabetes patients with ischemic cerebrovascular versus coronary Heart diseases at admission. Journal of Diabetes and Its Complications. 2015，29：783-787.（IF：3.005）
13.Huang D，Peng Y.Department of Neurology，Sun Yat-Sen Memorial Hospital. miR-340 suppresses glioblastoma multiforme. Oncotarget. 2015；6：9257-70.（IF：6.36）
14.Qiu S，Peng Y.Department of Neurology，Sun Yat-Sen Memorial Hospital. Chronic morphine-induced microRNA-124 promotes microglial immunosuppression by modulating P65 and TRAF6. J Immunol. 2015；194：1021-30.（IF：5.4）
15.Peng Y，Peng Ying.Department of Neurology，Sun Yat-Sen Memorial Hospital. Ornithine-δ-Aminotransferase Inhibits Neurogenesis During Xenopus Embryonic Development. Invest Ophthalmol Vis Sci. 2015 Mar 17［Epub ahead of print］.（IF：3.6）
16.Li H，Peng Y.Department of Neurology，Sun Yat-Sen Memorial Hospital. Autophagy biomarkers in CSF correlates with infarct size，clinicalseverity and neurological outcome in AIS patients .J Transl Med.83.9677662037037.（IF：3.9）
17.Li H，Peng Y.Department of Neurology，Sun Yat-Sen Memorial Hospital. Clinical Analysis in Chronic Alcoholic Encephalopathy：A Retrospective Study of 43 Subjects. Clinical Toxicology.2015，5：2.（IF：3.67）
18.Xu Y（通讯作者），Tang Y.Department of Neurology，Sun Yat-Sen Memorial Hospital. P2Y6 Receptor-Mediated Microglial Phagocytosis in Radiation-Induced Brain Injury. Mol Neurobiol.2015 Jun 23 ［Epub ahead of print］.（IF：5.137）
19.Xu T，Tang Y.Department of Neurology，Sun Yat-Sen Memorial Hospital. Extracellular ATP enhances radiationinduced brain injury through microglial activation and paracrine signaling via P2X7 receptor. Brain Behav Immun.2015 Nov；50：87-100.（IF：5.889）
20.Wen X，Liu Z.Department of Neurology，Sun Yat-Sen Memorial Hospital. Neuroprotective effect of astaxanthin against glutamate-induced cytotoxicity in HT22 cells：Involvement of the Akt/GSK-3βpathway. Neuroscience.2015；303：558-568.（IF：3.357）
21.Chen J，Yan Z.Department of Neurology，Sun Yat-Sen Memorial Hospital.TeachingNeuroImages：Primary Sjögren syndrome presenting as isolated lesion of medulla oblongata .Neurology.2015 Jan 6；84（1）：e5-6.（IF：8.3）
22.Xie haiqun，Chengguo zhang（corresponding author）．Foshan Hospital Affiliated to SunYat-senUniversity.Distinct Patterns of Cognitive Aging Modi fi ed by Education Level and Gender among Adults with Limited or No Formal Education：A Normative Study of the Mini-Mental State Examination. Journal of Alzheimer’ s Disease.2015；49：961-969.（IF：4.151）
23.聂坤，王丽娟（通讯作者）．广东省人民医院神经内科．RIT2 polymorphism is associated with Parkinson’s disease in a Han Chinese population. Neurobiol Aging.2015，36（3）：1603-1615.（IF：5.013）
24.Shu Y，Hu X（通讯作者）．中山大学附属第三医院．Urinary trypsin inhibitor levels are reduced in cerebrospinal fl uid of multiple sclerosis and neuromyelitis optica patients during relapse. Neurochem Int.2015 Feb；81：28-31.（IF：3.092）
25.Xiaobo Wei，Qing Wang（通讯作者）（2015）．中山大学附属第三医院．Contra-directional coupling of Nur77 and Nurr1 in Neurodegeneration：A novel mechanism for Memantine-induced anti-inflammation and antimitochondrial impairment. Molecular Neurobiology.Epub 2015 Oct 26.（IF：5.2.）
26.Chen D，Wang Q（通讯作者）（2015）．中山大学附属第三医院．Contra-Directional Expression of Serum Homocysteine and Uric Acid as Important Biomarkers of Multiple System Atrophy Severity：A Cross-Sectional Study. Front Cell Neurosci. 2015 Jul 6；9：247.（IF：4.3.）
27.Huimin Gao，Qing Wang（通讯作者）（2015）．中山大学附属第三医院．Lower bone mineral density in Patients with Parkinson’s disease：a cross-sectional study from Chinese Mainland. Front Aging Neurosci.2015；7：203.（IF：4.0.）
28.Yunqi Xu，Qing Wang（通讯作者）（2015）．中山大学附属第三医院．Low Cerebral Glucose Metabolism：A Potential Predictor for the Severity of Vascular Parkinsonism and Parkinson’s disease. Aging and Disease.2015；6（6）：426-436.（IF：3.1.）
29.Long L，Wang Q（通讯作者）（2015）．中山大学附属第三医院．Progressive supranuclear palsy：what do we know about it. Current Medicinal Chemistry. 22（10）：1182-93.（IF：3.715.）
30.Jiang Y，Chen X（通讯作者）．中山大学附属第三医院．Minocycline enhances hippocampal memory，neuroplasticity and synapse-associated proteins in aged C57 BL/6 mice .Neurobiol Learn Mem. 2015 May；121：20-9.（IF：3.652）
31.Zhang S，Liu G. Guangdong Key Laboratory of AgeRelated Cariac and Cerebral Diseases，Institute of Neurology，Af fi liated Hospital of Guangdong Medical College. CLU rs9331888 Polymorphism Contributes to Alzheimer’s Disease Susceptibility in Caucasian But Not East Asian Populations［J］. Mol Neurobiol.2016，53（3）：144651.（IF：5.137）
32.Xiao X，Bihl JC. Guangdong Key Laboratory of AgeRelated Cariac and Cerebral Diseases，Institute of Neurology，Af fi liated Hospital of Guangdong Medical College，Department of Pharmacology & Toxicology，Boonshoft School of Medicine，Wright State University. Angiotensin（17）counteracts angiotensin IIinduced dysfunction in cerebral endothelial cells via modulating Nox2/ROS and PI3K/NO pathways［J］. Exp Cell Res.2015，336：5865.（IF：3.246）
33.Tian W，Feng D. Guangdong Key Laboratory of AgeRelated Cariac and Cerebral Diseases，Institute of Neurology，Af fi liated Hospital of Guangdong Medical College，Department of Pharmacology & Toxicology，Boonshoft School of Medicine，Wright State University. Phosphorylation of ULK1 by AMPK regulates translocation of ULK1 to mitochondria and mitophagy［J］. FEBS Lett.2015，589：18471854.（IF：3.169）
34.Ma G，Li K. Guangdong Key Laboratory of AgeRelated Cariac and Cerebral Diseases，Institute of Neurology，Af fi liated Hospital of Guangdong Medical College. MiR206，a key modulator of skeletal muscle development and disease［J］. Int J Biol Sci.2015 Feb 5；11（3）：34552.（IF：4.509）
35.Liu Y，Ma X. Guangdong Key Laboratory of AgeRelated Cariac and Cerebral Diseases，Institute of Neurology，Affiliated Hospital of Guangdong Medical College，Department of Pharmacology & Toxicology，Boonshoft School of Medicine，Wright State University. MicroRNA155 Regulates ROS Production，NO Generation，Apoptosis and Multiple Functions of Human Brain Microvessel Endothelial Cells Under Physiological and Pathological Conditions［J］. J Cell Biochem.2015，116：28702881 ．（IF：3.263）
36.Liu SY，Li KS. Guangdong Key Laboratory of AgeRelated Cariac and Cerebral Diseases，Institute of Neurology，Affiliated Hospital of Guangdong Medical College. Association between Polymorphisms of the AKT1 Gene Promoter and Risk of the Alzheimer’s Disease in a Chinese Han Population with Type 2 Diabetes［J］. CNS Neurosci Ther.2015，21：619625.（IF：3.931）
37.Liu S，Li K. Guangdong Key Laboratory of AgeRelated Cariac and Cerebral Diseases，Institute of Neurology，Af fi liated Hospital of Guangdong Medical College.The nitric oxide synthase 3 G894T polymorphism associated with Alzheimer’s disease risk：a metaanalysis［J］. Sci Rep.2015，5：13598.（IF：5.578）
38.Liu G，Liu J. Guangdong Key Laboratory of AgeRelated Cariac and Cerebral Diseases，Institute of Neurology，Affiliated Hospital of Guangdong Medical College. Convergent Genetic and Expression Datasets Highlight TREM2 in Parkinson’s Disease Susceptibility［J］. Mol Neurobiol. 2015 Sep 14.（IF：5.137）
39.Liu G，Li K. Guangdong Key Laboratory of AgeRelated Cariac and Cerebral Diseases，Institute of Neurology，Affiliated Hospital of Guangdong Medical College. CHCHD2 and Parkinson’s disease［J］. Lancet Neurol.2015，14：679680.（IF：21.896）
40.Liu G，Li K. Guangdong Key Laboratory of AgeRelated Cariac and Cerebral Diseases，Institute of Neurology，Af fi liated Hospital of Guangdong Medical College. Identifying the Association Between Alzheimer’s Disease and Parkinson’s Disease Using GenomeWide Association Studies and ProteinProtein Interaction Network［J］. Mol Neurobiol.2015，52：16291636.（IF：5.137）
41.Li K，Liu G. Guangdong Key Laboratory of AgeRelated Cariac and Cerebral Diseases，Institute of Neurology，Af fi liated Hospital of Guangdong Medical College.REST rs3796529 variant does not confer susceptibility to Alzheimer’s disease［J］. Ann Neurol.2015，78：835836.（IF：9.977）
42.Li H，Yao D. Guangdong Key Laboratory of AgeRelated Cariac and Cerebral Diseases，Institute of Neurology，Affiliated Hospital of Guangdong Medical College. Estradiol mediates vasculoprotection via ERRalphadependent regulation of lipid and ROS metabolism in the endothelium［J］. J Mol Cell Cardiol.2015，87：92101.（IF：4.655）
43.Gu X，Li K. Guangdong Key Laboratory of AgeRelated Cariac and Cerebral Diseases，Institute of Neurology，Af fi liated Hospital of Guangdong Medical College. Silencing of RSpondin1 increases radiosensitivity of glioma cells［J］. Oncotarget.2015，6：97569765.（IF：6.359）
44.Gu X，Li K. Guangdong Key Laboratory of AgeRelated Cariac and Cerebral Diseases，Institute of Neurology，Affiliated Hospital of Guangdong Medical College，Department of Pharmacology & Toxicology，Boonshoft School of Medicine，Wright State University. Efficient inhibition of human glioma development by RNA interferencemediated silencing of PAK5［J］. Int J Biol Sci.2015，11：230237.（IF：4.509）
45.Bihl JC，Zhao B. Guangdong Key Laboratory of AgeRelated Cariac and Cerebral Diseases，Institute of Neurology，Af fi liated Hospital of Guangdong Medical College，Department of Pharmacology & Toxicology，Boonshoft School of Medicine，Wright State University. Angiotensin（17）counteracts the effects of Ang II on vascular smooth muscle cells，vascular remodeling and hemorrhagic stroke：Role of the NFsmall ka，CyrillicB in fl ammatory pathway［J］. Vascul Pharmacol. 2015，73：115123.（IF：3.635）
46.Bao X，Li K. Guangdong Key Laboratory of AgeRelated Cariac and Cerebral Diseases，Institute of Neurology，Affiliated Hospital of Guangdong Medical College. Cell adhesion molecule pathway genes are regulated by cisregulatory SNPs and show significantly altered expression in Alzheimer’s disease brains［J］. Neurobiol Aging.2015，36：2904 e29012907.（IF：5.013）
贵州省
1.楚兰（通讯作者），戴庆箐（共同第一作者）．贵州医科大学附属医院．Association Between the Single Nucleotide Polymorphism and the Level of Aquaporin-4 Protein Expression in Han and Minority Chinese with In fl ammatory Demyelinating Diseases of the Central Nervous System. Molecular Neurobiology.2015 Apr 18 PubMed PMID：25895050.（IF：5.137）
2.徐竹，贺电（通讯作者）．贵州医科大学附属医院．Dimethyl fumarate for multiple sclerosis. Cochrane Database of Systematic Reviews.2015，Issue 4 Art No：CD011076.（IF：6.032）
3.贺电，楚兰（通讯作者）．贵州医科大学附属医院．Intravenous immunoglobulin for Alzheimer’s disease（protocol）． Cochrane Database of Systematic Reviews. 2015；Issue 8 Art No：CD011827.（IF：6.032）
4.Liu T，Pan S（通讯作者）．People’s Hospital of Hainan Province.Neurochemical abnormalities in anterior cingulate cortex on betel quid dependence：a 2D（1）H MRS investigation. Am J Transl Res. 2015；7（12）：2795-804.（IF：3.402）
河北省
1.Guo Y1，Xu Z（通讯作者）．河北医科大学第二医院．A Single Injection of Recombinant AdenoAssociated Virus into the Lumbar Cistern Delivers TransgeneExpression Throughout the Whole Spinal Cord. Mol Neurobiol.2015 Jun 7［Epub ahead of print］.（IF：5.137）
2.Cui L，Zhao LR（通讯作者．河北医科大学第二医院．NFκB is involved in brain repair by stem cell factor and granulocytecolony stimulating factor in chronic stroke .Exp Neurol.2015 Jan；263：1727.（IF：4.696）
3.Xiaoyun Liu，WangWang（通讯作者）．河北医科大学第二医院．Transient mitochondrial permeability transition mediates excitotoxicity in glutamatesensitive NSC34D motor neuronlike cells .Experimental Neurology.2015 Sep；271：12230.（IF：4.696）
4.Zhu Y（通讯作者），Yan C.河北医科大学第二医院．Reduced Serum Level of Interleukin10 is Associated with Cerebral Infarction：A CaseControl and MetaAnalysis Study .Mol Neurobiol.2015 Aug 8 ［Epub ahead of print］.（IF：5.137）
5.Zhao J，Zhang X（通讯作者）Li L.河北医科大学第二医院．Cinnamaldehyde inhibits in fl ammation and brain damage in a mouse model of permanent cerebral ischaemia. Br J Pharmacol.2015 Oct；172（20）：500923.（IF：4.842）
6.Li Y，Li C（通讯作者）．河北医科大学第二医院．Trehalose decreases mutant SOD1 expression and alleviates motor deficiency in early but not endstage amyotrophic lateral sclerosis in a SOD1G93A mouse model. Neuroscience.2015 Jul 9；298：1225.（IF：3.357）
7.Wen Y，Zhang X（通讯作者）Zhu C.河北医科大学第二医院．Acetylbritannilactone Modulates MicroRNA155Mediated Inflammatory Response in Ischemic Cerebral Tissues .Mol Med.2015 Mar 18；21：197209.（IF：4.508）
黑龙江省
1.李国忠（通讯作者）．哈尔滨医科大学附属第一医院．Damage effect of interleukin（IL）-23 on oxygen-glucosedeprived cells of the neurovascular unit via IL-23 receptor. Neuroscience.2015（3），289：406-416.（IF：3.357）
2.李国忠（通讯作者）．哈尔滨医科大学附属第一医院．Pivotal role of cerebral interleukin-23 during immunologic injury in delayed cerebral ischemia in mice. Neuroscience.2015（4），290：321-331.（IF：3.357）
3.李仙锋（通讯作者）．哈尔滨医科大学附属第一医院．Stable knockdown of LRG1 by RNA interference inhibits growth and promotes apoptosis of glioblastoma cells in vitro and in vivo. Tumor Biology.2015（6），36：4271-4278.（IF：3.611）
4.段淑荣（通讯作者）．哈尔滨医科大学附属第一医院．Identi fi cation of Pivotal Markers in Vascular Dementia Based on Proteomics Data .Dement Geriatr Cogn Disord.2015（10），39：312-320.（IF：3.547）
5.张黎明（通讯作者）．哈尔滨医科大学附属第一医院．Computational identi fi cation of epigenetically regulated lncRNAs and their associated genes based on integrating genomic data. febs letters.2015（2）：521-531.（IF：3.169）
6.张黎明（通讯作者）．哈尔滨医科大学附属第一医院．Identification of cancer-related lncRNAs through integrating genome，regulome and transcriptome features. Molecular biosystems.2015（1），11：126-136.（IF：3.21）
7.丰宏林（通讯作者）．哈尔滨医科大学附属第一医院．Allopurinol reduces severity of delayed neurologic sequelae in experimental carbon monoxide toxicity in rats. NeuroToxicology.2015（5），48：171-179.（IF：3.379）
8.丰宏林（通讯作者）．哈尔滨医科大学附属第一医院．Notch pathway is activated in cell culture and mouse models of mutant SOD1-related familial amytrophic lateral sclerosis with suppression of its activation as an additional mechanism of neuroprotection for lithium and valproate .Neuroscience.2015（8），301：276-288（IF：3357）．（IF：3.357）
9.丰宏林，崔尚今（通讯作者）．哈尔滨医科大学附属第一医院．Roscovitine treatment caused impairment of fertilizing ability in mice. Toxicology Letters.2015（7），237：200-209.（IF：3.262）
10.丰宏林（通讯作者）．哈尔滨医科大学附属第一医院．Corpus callosum atrophy associated with the degree of cognitive decline in patients with Alzheimer’s dementia or mild cognitive impairment：A meta-analysis of the region of interest structural imaging studies. Journal of Psychiatric Research.2015（4），63：010-019.（IF：3.957）
11.丰宏林（通讯作者）．哈尔滨医科大学附属第一医院．Downregulated AEG-1 together with inhibited PI3K/Akt pathway is associated with reduced viability of motor neurons in an ALS model.Molecular and Cellular Neuroscience.2015（9），68：303-313.（IF：3.84）
河南省
Shi J，Tan S，et al.河南科技大学第一附属医院．Severe instead of mild hyperglycemia inhibits neurogenesis in the subventricular zone of adult rats after transient focal cerebral ischemia .Neuroscience.2015；303（7）．（IF：3.357）
湖北省
1.唐洲平（通讯作者）Hu Y，Aimaiti M1，Zhang Y1，Zhou H2，Wu G3，Tang Z4.华中科技大学同济医学院附属同济医院神经内科．Preclinical Studies of Stem Cell Transplantation in Intracerebral Hemorrhage：a Systemic Review and Meta-Analysis .Mol Neurobiol.2015 Sep 26.［Epub ahead of print］.（IF：5.137）
2.田代实（通讯作者）Qu WS.华中科技大学同济医学院附属同济医院神经内科．Rapidly activated epidermal growth factor receptor mediates lipopolysaccharide-triggered migration of microglia． Neurochem Int.2015 Nov；90：85-92.（IF：3.092）
3.田代实（通讯作者）Li CY1.华中科技大学同济医学院附属同济医院神经内科．Inhibition of mTOR pathway restrains astrocyte proliferation，migration and production of inflammatory mediators after oxygen-glucose deprivation and reoxygenation. Neurochem Int.2015 Apr-May；83-84：9-18.（IF：3.092）
4.朱遂强（通讯作者）Zhang N1.华中科技大学同济医学院附属同济医院神经内科．Adult medulloblastoma：clinical characters，prognostic factors，outcomes and patterns of relapse. Journal of Neuro-Oncology.2015，124（0）：255.（IF：3.07）
5.谢敏杰（通讯作者）Chen X，.华中科技大学同济医学院附属同济医院神经内科．Soluble epoxide hydrolase inhibition provides multi-target therapeutic effects in rats after spinal cord injury. Mol Neurobiol.2015 Feb 10.［Epub ahead of print］.（IF：5.137）
6.王伟（通讯作者）Jing L.华中科技大学同济医学院附属同济医院神经内科．Targeted Inhibitory Effect of Lenti-SM22alpha-p27-EGFP Recombinant Lentiviral Vectors on Proliferation of Vascular Smooth Muscle Cells without Compromising Re-Endothelialization in a Rat Carotid Artery Balloon Injury Model. PLoS One.2015 Mar 11；10（3）：e0118826.（IF：3.234）
湖南省
1.龙莉莉，肖波．中南大学湘雅医院．Levamisole-induced leukoencephalopathy mimicking Baló disease. NEUROLOGY.2015，84（3）：328.（IF：8.303）
2.Xiao-Jun Huang，唐北沙（并列通讯作者）．中南大学湘雅医院．Paroxysmal kinesigenic dyskinesia Clinical and gentic analyses of 110 patients .Neurology.2015，85（18）：1546-1553.（IF：8.303）
3.Zeng Ling-Li，肖波（并列通讯作者）．中南大学湘雅医院．Gray Matter Loss and Related Functional Connectivity Alterations in a Chinese Family With Benign Adult Familial Myoclonic Epilepsy. MEDICINE.2015，94（42）：e1767.（IF：5.723）
4.宋延民，刘运海．中南大学湘雅医院．TLR4 rs1927911，but Not TLR2 rs5743708，Is Associated With Atherosclerotic Cerebral Infarction in the Southern Han Population A Case-Control Study. MEDICINE.2015，94（2）：e381.（IF：5.723）
5.张萌琦，肖波．中南大学湘雅医院．Ultra-high-resolution 3D digitalized imaging of the cerebral angioarchitecture in rats using synchrotron radiation.SCI REP-UK.2015，5：14982.（IF：5.578）
6.曾畅，肖波，田发发（并列通讯作者）．中南大学湘雅医院．Upregulation and Diverse Roles of TRPC3 and TRPC6 in Synaptic Reorganization of the Mossy Fiber Pathway in Temporal Lobe Epilepsy .MOL NEUROBIOL.2015，52（1）：562-572.（IF：5.137）
7.李凯，郭纪锋．中南大学湘雅医院．LRRK2 A419V variant is a risk factor for Parkinson’s disease in Asian population. NEUROBIOL AGING.2015，36（10）：2908e11-5.（IF：5.013）
8.刘振华，唐北沙．中南大学湘雅医院．Assessment of RIT2 rs12456492 association with Parkinson’s disease in Mainland China .NEUROBIOL AGING.2015，36（3）：1600e9-1600e11.（IF：5.013）
9.郭纪锋，唐北沙．中南大学湘雅医院．Polygenic Determinants of Parkinson’s Disease in a South China population. NEUROBIOL AGING.2015，36（4）：1765e1-1765e6.（IF：5.013）
10.罗月贝，Frank Mastaglia.中南大学湘雅医院．Dermatomyositis，polymyositis and immune-mediated necrotising myopathies .BBA-MOL BASIS DIS.2015，1852（4）：622-32.（IF：4.882）
11.Alsharafi WA，肖波．中南大学湘雅医院．miRNAs：biological and clinical determinants in epilepsy .Front Mol Neurosci.8：59.2015-10-13.（IF：4.289）
12.Alsharafi WA，肖波．中南大学湘雅医院．Correlation Between IL-10 and microRNA-187 Expression in Epileptic Rat Hippocampus and Patients with Temporal Lobe Epilepsy. Front Mol Neurosci.9：466.2015-10-13.（IF：4.289）
13.廖鑫鑫，沈璐．中南大学湘雅医院．SPG35 contributes to the second common subtype of AR-HSP in China：frequency analysis and functional characterization of FA2H gene mutations .CLIN GENET.2015，87（1）：85-89.（IF：3.931）
14.张俊美，李静．中南大学湘雅医院．Silencing miR-146a influences B cells and ameliorates experimental autoimmune myasthenia gravis. IMMUNOLOGY.2015，144（1）：56-67.（IF：3.795）
15.唐昭黎，江泓．中南大学湘雅医院．Primary erythromelalgia：a review. ORPHANET J RARE DIS.32015，10：127.（IF：3.958）
16.曾艺，张乐．中南大学湘雅医院．807C/T polymorphism of platelet glycoprotein Ia gene is associated with cerebral hemorrhage in a Chinese population. NEUROSCIENCE.，3 2015，1（1）：1-5.（IF：3.357）
17.陈召，江泓．中南大学湘雅医院．Targeted Next-Generation Sequencing Revealed Novel Mutations in Chinese Ataxia Telangiectasia Patients：A Precision MEDICINE Perspective. PLOS ONE.2015，10（10）：e0139738.（IF：3.234）
18.杨样，郭纪锋．中南大学湘雅医院．Genetic Identification Is Critical for the Diagnosis of Parkinsonism：A Chinese Pedigree with Early Onset of Parkinsonism. PLOS ONE.2015，10（8）：e0136245.（IF：3.234）
19.王春荣，江泓．中南大学湘雅医院．Analysis of the GGGGCC Repeat Expansions of the C9orf72 Gene in SCA3/MJD Patients from China. PLOS ONE.2015，10（6）：e0130336.（IF：3.234）
20.黄凤珍，江泓．中南大学湘雅医院．Investigation of Gene Regulatory Networks Associated with Autism Spectrum Disorder Based on MiRNA Expression in China. PLOS ONE.2015，10（6）：e0129052.（IF：3.234）
21.龙哲，江泓．中南大学湘雅医院．Two novel SNPs in ATXN3 3’ UTR may decrease age at onset of SCA3/MJD in Chinese patients. PLOS ONE.2015，10（2）：e0117488.（IF：3.234）
22.Wei Li，Deren Hou（通讯作者）．Department of Neurology，The Third Xiangya Hospital，Central SouthUniversit.Relationship between Adiponectin Gene Polymorphisms and Late-Onset alzheimer’s Disease. PLoS One.2015，10（4）．（IF：3.234）
江苏省
1.Han L，Xu Y（通讯作者）．南京大学医学院附属鼓楼医院神经内科．Rosiglitazone Promotes White Matter Integrity and Long-Term Functional Recovery After Focal Cerebral Ischemia .Stroke.2015，46（9）：2628-2636.（IF：5.723）
2.Li T，Xu Y（通讯作者）．南京大学医学院附属鼓楼医院神经内科．Human umbilical cord mesenchymal stem cells：an overview of their potential in cell-based therapy. Expert Opin Biol Ther.2015 Jun 12：1-14.（IF：3.743）
3.Zhao H，Xu Y（通讯作者）．南京大学医学院附属鼓楼医院神经内科．Atrophic Patterns of the Frontal-Subcortical Circuits in Patients with Mild Cognitive Impairment and Alzheimer’s Disease［J］. PLoS One.2015，10（6）：e0130017.（IF：3.234）
4.Jin JL，Xu Y（通讯作者）．南京大学医学院附属鼓楼医院神经内科．CART treatment improves memory and synaptic structure in APP/PS1 mice .Sci Rep.2015，5：10224.（IF：5.078）
5.Pan J，Xu Y（通讯作者）．南京大学医学院附属鼓楼医院神经内科．Malibatol A regulates microglia M1/M2 polarization in experimental stroke in a PPARγ-dependent manner［J］. J Neuroinflammation.2015，12（1）：51.（IF：5.408）
6.Li H，Xu Y（通讯作者）．南京大学医学院附属鼓楼医院神经内科．The Roles of Variants in Human Multidrug Resistance（MDR1）Gene and Their Haplotypes on Antiepileptic Drugs Response：A Meta-Analysis of 57 Studies. PLoS One.2015，10（3）：e0122043.（IF：3.234）
7.Yang W，Xu Y（通讯作者）．南京大学医学院附属鼓楼医院神经内科．Malibatol A protects against brain injury through reversing mitochondrial dysfunction in experimental Stroke .Neurochem Int.2015，80：33-40.（IF：3.092）
8.Zhang B，Xu Y（通讯作者）．南京大学医学院附属鼓楼医院神经内科．Characterizing Topological Patterns in Amnestic Mild Cognitive Impairment by Quantitative Water Diffusivity［J］. J Alzheimers Dis.2015，43（2）：687-697.（IF：4.15）
9.Han L，Xu Y（通讯作者）．南京大学医学院附属鼓楼医院神经内科．Human Urinary Kallidinogenase Promotes Angiogenesis and Cerebral Perfusion in Experimental Stroke［J］ .PLoS One.2015，10（7）：e0134543.（IF：3.234）
10.Wang L，Xu Y（通讯作者）．南京大学医学院附属鼓楼医院神经内科．Conditional inactivation of Akt three isoforms causes tau hyperphosphorylation in the brain .Mol Neurodegener.2015，10（1）：1-7.（IF：6.563）
11.Wang S，Xu Y（通讯作者）．南京大学医学院附属鼓楼医院神经内科．Oridonin attenuates Aβ1-42-induced neuroin fl ammation and inhibits NF-κB pathway. PLoS One.2014，9（8）：e104745.（IF：3.234）
12.Zhang M，Xu Y（通讯作者）．南京大学医学院附属鼓楼医院神经内科．PSD-93 deletion inhibits Fynmediated phosphorylation of NR2B and protects against focal cerebral ischemia. Neurobiol Dis.2014，68：104-11.（IF：5.078）
13.Zhu X，Xu Y（通讯作者）．南京大学医学院附属鼓楼医院神经内科．Hydroxy-safflor yellow A attenuates Aβ1-42-induced inflammation by modulating the JAK2/STAT3/NF-κB pathway. Int J Neuropsychopharmacol.2014，17（9）：1511-1519.（IF：4.009）
14.Lin Y，Xu Y（通讯作者）．南京大学医学院附属鼓楼医院神经内科．The Association between CYP2C19 Genotype and of In-stent Restenosis among Patients with Vertebral Artery Stent Treatment.CNS Neurosci Ther.2014，20（2）：125-30.（IF：3.931）
15.Liu A，Xu Y（通讯作者）．南京大学医学院附属鼓楼医院神经内科．High Cytochrome c Oxidase Expression Links to Severe Skeletal Energy Failure by 31 P-MRS Spectroscopy in Mitochondrial Encephalomyopathy，Lactic Acidosis，and Stroke-Like Episodes .CNS Neurosci Ther.2014，20（6）：509-514.（IF：3.931）
16.Zhang M，Xu Y（通讯作者）．南京大学医学院附属鼓楼医院神经内科．Omega-3 Fatty Acids Protect the Brain against Ischemic Injury by Activating Nrf2 and Upregulating Heme Oxygenase 1. J Neurosci.2014，34（5）：1903-15.（IF：6.344）
17.Chen Y，Xu Y（通讯作者）．南京大学医学院附属鼓楼医院神经内科．Swanson RA Targeting Microglial Activation in Stroke Therapy：Pharmacological Tools and Gender Effects. Curr Med Chem.2014，21（19）：2146.（IF：3.853）
18.Zhang Z，Liu X（通讯作者）．南京军区南京总医院神经内科．A Novel Functional Polymorphism in the NINJ2 Promoter Predicts Risk of Large Artery Atherosclerotic Stroke.Molecular Neurobiology.2015 Dec 19.（IF：5.137）
19.Liu R，Liu X（通讯作者）．南京军区南京总医院神经内科．An Optical Coherence Tomography Assessment of Stent Strut Apposition Based on the Presence of Lipid-Rich Plaque in the Carotid Artery .Journal of Endovascular Therapy.2015；22（6）：942-9.（IF：3.353）
20.Huang Z，Liu X（通讯作者）．南京军区南京总医院神经内科．Reduced endothelial progenitor cells in extracranial arterial stenosis but not intracranial arterial stenosis .Journal of Vascular Surgery.2015；62（6）：1539-45.（IF：3.021）
21.Zhang Z，Liu X（通讯作者）．南京军区南京总医院神经内科．PRKCH 1425G/A Polymorphism Predicts Recurrence of Ischemic Stroke in a Chinese Population. Molecular Neurobiology.2015；52（3）：1648-53.（IF：5.286）
22.Sun L，Zhang Z（通讯作者）Liu X.南京军区南京总医院神经内科．Dietary Fiber Intake Reduces Risk for Barrett’s Esophagus and Esophageal Cancer. Critical Reviews in Food Science and Nutrition.2015 Oct 13：0.（IF：5.176）
23.Zhang J，Xu G（通讯作者）．南京军区南京总医院神经内科．Letter by Zhang et al Regarding Article，“Hypotension During Endovascular Treatment of Ischemic Stroke Is a Risk Factor for Poor Neurological Outcome”. Stroke.2015；46（11）：e237.（IF：5.723）
24.Jiang Y，Liu X（通讯作者）．南京军区南京总医院神经内科．Intranasal delivery：circumventing the iron curtain to treat neurological disorders. Expert Opinion on Drug Delivery.2015；12（11）：1717-25.（IF：4.84）
25.Xie Y，Liu X（通讯作者）．南京军区南京总医院神经内科．Human Albumin Improves Long-Term Behavioral Sequelae After Subarachnoid Hemorrhage Through Neurovascular Remodeling. Critical Care Medicine.2015；43（10）：e440-9.（IF：6.312）
26.Sun L，Liu X.南京军区南京总医院神经内科．Chromosome 4q25 Variants rs2200733，rs10033464，and rs1906591 Contribute to Ischemic Stroke Risk. Molecular Neurobiology.2015 Jul 11.（IF：5.137）
27.Liu R，Liu X（通讯作者）．南京军区南京总医院神经内科．Letter by Liu et al Regarding Article，“Leukoaraiosis Burden Signi fi cantly Modulates the Association Between Infarct Volume and National Institutes of Health Stroke Scale in Ischemic Stroke”. Stroke.2015；46（8）：e196.（IF：5.723）
28.Xiao L，Liu X（通讯作者）．南京军区南京总医院神经内科．Chronic Kidney Disease in Patients With Lacunar Stroke：Association With Enlarged Perivascular Spaces and Total Magnetic Resonance Imaging Burden of Cerebral Small Vessel Disease. Stroke.2015；46（8）：2081-6.（IF：5.723）
29.Zhang Y，Xu G（通讯作者）．南京军区南京总医院神经内科．Shared and discrepant susceptibility for carotid artery and aortic arch calci fi cation：A genetic association study. Atherosclerosis.2015；241（2）：371-375.（IF：3.994）
30.Lan W，Zhang R（通讯作者）．南京军区南京总医院神经内科．Human urine kininogenase attenuates ballooninduced intimal hyperplasia in rabbit carotid artery through transforming growth factor β 1/Smad2/3 signaling pathway. Journal of Vascular Surgery.2015 Jun 5.（IF：3.021）
31.Cai B，Xu G（通讯作者）．南京军区南京总医院神经内科．Mitochondrial DNA haplogroups and short-term neurological outcomes of ischemic Stroke. Scienti fi c Reports.2015；5：9864.（IF：5.578）
32.Jiang Y，Liu X（通讯作者）．南京军区南京总医院神经内科．In-stent restenosis after vertebral artery stenting. International Journal of Cardiology.2015；187：430-433.（IF：6.175）
33.Dai Q，Liu X（通讯作者）．南京军区南京总医院神经内科．From clinical to tissue-based dual TIA：Validation and re fi nement of ABCD3-I score. Neurology.2015；84（14）：1426-32.（IF：8.303）
34.Zhang Z，Liu X（通讯作者）．南京军区南京总医院神经内科．Nut consumption and risk of Stroke. European Journal of Epidemiology.2015；30（3）：189-96.（IF：5.147）
35.Xu L，Ye R（通讯作者）．南京军区南京总医院神经内科．Caveolae：molecular insights and therapeutic targets for Stroke. Expert Opinion on Therapeutic Targets.2015；2：1-18.（IF：5.139）
36.Zhu J，Liu X（通讯作者）．南京军区南京总医院神经内科．Enhanced angiogenesis promoted by human umbilical mesenchymal stem cell transplantation in stroked model is notch1 signaling associated. Neuroscience.2015；290：288-99.（IF：3.327）
37.Yang L，Xu G（通讯作者）．南京军区南京总医院神经内科．Over-expressed EGR1 may exaggerate ischemic injury after experimental stroke by decreasing BDNF expression.Neuroscience.2015；290：509-17.（IF：3.327）
38.Xiong Y，Liu X（通讯作者）．南京军区南京总医院神经内科．The safety and long-term outcomes of angioplasty and stenting in symptomatic intracranial atherosclerotic stenosis. International Journal of Cardiology.2015；179：23-4.（IF：6.175）
39.Rong Rong，Qingxiu Zhang（Corresponding author）．Department of Neurology，Second Affiliated Hospital of Xuzhou Medical College.Proteomic analysis of PSD-93 knockout mice following the induction of ischemic cerebral injury. NeuroToxicology.2016，53：1-11.（IF：3.379）
40.张勇．徐州医科大学附属医院．TIPE2 Play a Negative Role in TLR4-Mediated Autoimmune T Helper 17 Cell Responses in Patients with Myasthenia Gravis. J Neuroimmune Pharmacol.2015 Oct 24 ［Epub ahead of print］.（IF：4.11）
41.张勇．徐州医科大学附属医院．Exploring the role of interleukin-22 in neurological and autoimmune disorders. Int Immunopharmacol.2015 Oct；28（2）：1076-83.（IF：2.472）
42.张勇．徐州医科大学附属医院．Decreased microRNA miR-181c expression in peripheral blood mononuclear cells correlates with elevated serum levels of IL-7 and IL-17 in patients with myasthenia gravis. Clin Exp Med.2015 May 12 ［Epub ahead of print］.（IF：2.959）
43.张勇．徐州医科大学附属医院．RNA interference targeting Bcl-6 ameliorates experimental autoimmune myasthenia gravis in mice. Mol Cell Neurosci.2014 Jan；58：85-94.（IF：3.84）
44.张勇，耿德勤（通信作者）．徐州医科大学附属医院．Hypothalamus Syndrome in Opticospinal Multiple Sclerosis.American Journal of Neuroradiology.2011；3174：2178-90.（IF：3.3）
45.耿德勤（通信作者）．徐州医科大学附属医院．The inhibition of erk activation mediates the protection of necrostatin-1 on glutamate toxicity in ht-22 cells. Neurotoxicity research.2013 Jan 10 ［Epub ahead of print］.（IF：3.5）
46.耿德勤（通信作者）．徐州医科大学附属医院．RIP1 mediates the protection of geldanamycin oneuronal injury induced by oxygen-glucose deprivation combined with zVAD in primary cortical neurons. Journal of Neurochemistry.2012，120：70-77.（IF：4.3）
47.Pan X，Yang J（杨杰，通讯作者）．南京医科大学附属南京医院．Prior antiplatelet agent use and outcomes after intravenous thrombolysis with recombinant tissue plasminogen activator in acute ischemic stroke：a metaanalysis of cohort studies and randomized controlled trials.Int J Stroke.2015；10（4）：317-323.（IF：3.833）
48.Yang J（杨杰），Anderson CS（通讯作者）．南京医科大学附属南京医院．Prognostic Significance of Perihematomal Edema in Acute Intracerebral Hemorrhage：Pooled Analysis From the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial Studies. Stroke.2015；46（4）：1009-1013.（IF：5.723）
49.Jiang T，Zhang YD（张颖冬，通讯作者）．南京医科大学附属南京医院．Silencing of TREM2 exacerbates tau pathology，neurodegenerative changes，and spatial learning deficits in P301S tau transgenic mice. Neurobiol Aging.2015；36（12）：3176-86.（IF：5.013）
50.Jiang T（蒋腾），Tan L（通讯作者）．南京医科大学附属南京医院．Angiotensin-（1-7）is Reduced and Inversely Correlates with Tau Hyperphosphorylation in Animal Models of Alzheimer’s Disease. Mol Neurobiol.2015；6（5）．（IF：5.137）
51.Gao Q，Zhang YD（张颖冬，通讯作者）．南京医科大学附属南京医院．Activation of Autophagy Contributes to the AngiotensinⅡTriggered Apoptosis in a Dopaminergic Neuronal Cell Line. Mol Neurobiol.2015；4（23）．（IF：5.137）
52.Zhang QQ，Zhang YD（张颖冬，通讯作者）．南京医科大学附属南京医院．Common Polymorphisms Within QPCT Gene Are Associated with the Susceptibility of Schizophrenia in a Han Chinese Population. Mol Neurobiol.2015；11（16）．（IF：5.137）
53.Li T，Chen Y（通讯作者），Xu Y（通讯作者）．南京大学医学院附属鼓楼医院．Human umbilical cord mesenchymal stem cells：an overview of their potential in cell-based therapy ［J］ .Expert opinion on biological therapy.2015，15（9）：1293-1306.（IF 3.743）
54.Zhao H，Zhang B（通讯作者），Xu Y（通讯作者）．南京大学医学院附属鼓楼医院．Atrophic Patterns of the Frontal-Subcortical Circuits in Patients with Mild Cognitive Impairment and Alzheimer’s Disease ［J］. PLoS One.2015，10（6）：e0130017.（IF 3.234）
55.Jin J-l，Xu Y（通讯作者）．南京大学医学院附属鼓楼医院．CART treatment improves memory and synaptic structure in APP/PS1 mice ［J］. Scienti fi c Reports.2015，5：10224.（IF 5.578）
56.Pan J，Xu Y（通讯作者）．南京大学医学院附属鼓楼医院．Malibatol A regulates microglia M1/M2 polarization in experimental stroke in a PPARγ-dependent manner ［J］. Journal of neuroin fl ammation.2015，12（1）：51.（IF 5.408）
57.Li H，Xu Y（通讯作者），Jiang Y（通讯作者）．南京大学医学院附属鼓楼医院．The Roles of Variants in Human Multidrug Resistance（MDR1）Gene and Their Haplotypes on Antiepileptic Drugs Response：A Meta-Analysis of 57 Studies ［J］. PLoS One.2015，10（3）：e0122043.（IF 3.234）
58.Yang W，Xu Y（通讯作者）．南京大学医学院附属鼓楼医院．Malibatol A protects against brain injury through reversing mitochondrial dysfunction in experimental stroke ［J］. Neurochemistry international.2015，80：33-40.（IF 3.092）
59.Zhang B，Xu Y（通讯作者），Zhu B（通讯作者）．南京大学医学院附属鼓楼医院．Characterizing Topological Patterns in Amnestic Mild Cognitive Impairment by Quantitative Water Diffusivity ［J］ .Journal of Alzheimer’s disease：JAD.2015，43（2）：687-697.. （IF 4.151）
60.Han L，Xu Y（通讯作者），Chen J（通讯作者）．南京大学医学院附属鼓楼医院．Rosiglitazone promotes white matter integrity and long-term functional recovery after focal cerebral ischemia ［J］. Stroke.2015，46（9）：2628-2636.（IF 5.723）
61.Han L，Xu Y（通讯作者），Li J（通讯作者）．南京大学医学院附属鼓楼医院．Human urinary kallidinogenase promotes angiogenesis and cerebral perfusion in experimental stroke ［J］. PLoS One.2015，10（7）：e0134543.（IF 3.234）
62.Wang L，Xu Y（通讯作者），Yang Z（通讯作者），Chen G（通讯作者）．南京大学医学院附属鼓楼医院．Conditional inactivation of Akt three isoforms causes tau hyperphosphorylation in the brain ［J］. Molecular neurodegeneration.2015，10（1）：1-7.（IF 6.563）
63.Chen Y.南京大学医学院附属鼓楼医院．Brennan-Minnella AM，Sheth S，El-Benna J，Swanson RA（通讯作者）．Tat-NR2B9c prevents excitotoxic neuronal superoxide production. J Cereb Blood Flow Metab.2015 May；35（5）：739-42.（IF 5.407）
辽宁省
1.朱颖，何志义．中国医科大学附属第一医院．Association of Altered Serum MicroRNAs with Perihematomal Edema after Acute Intracerebral Hemorrhage. PLoS One.2015；10（7）：e0133783.（IF：3.234）
2.宋程光，赵传胜．中国医科大学附属第一医院．CXCR4 Antagonist AMD3100 Suppresses the Long-Term Abnormal Structural Changes of Newborn Neurons in the Intraventricular Kainic Acid Model of Epilepsy. Mol Neurobiol.2015 Feb 4 ［Epub ahead of print］.（IF：5.137）
3.曲慧玲，赵传胜．中国医科大学附属第一医院．Forced limb-use enhanced neurogenesis and behavioral recovery after stroke in the aged rats. Neuroscience.2015；286：316-324.（IF：3.357）
4.王尚，赵传胜（通讯作者）．中国医科大学附属第一医院．In vivo Effect of bumetanide at brain concentrations incompatibLe With NKCC1 inhibition on newborn DGC structure and spontanous EEG seizures following hypoxia-induced neonatal seizurea. Neuroscience.2015；286：203-215.（IF：3.357）
5.孙晓羽，赵传胜．中国医科大学附属第一医院．Fluoxetine enhanced neurogenesis is aged rats with cortical infarcts but this is not re fl ected in a behavioral recovery. J Mol Neurosci.2015；58（2）：233-242.（IF：5.137）
6.Zhang S，Feng J.中国医科大学附属盛京医院．Clinicoradiological Spectrum of Reversible Splenial Lesion Syndrome（RESLES）in Adults：A Retrospective Study of a Rare Entity. Medicine.2015；94（6）：1-12.（IF：5.723）
7.Fan B/Fan B.中国医科大学附属盛京医院．Pycnogenol Attenuates the Release of Proin fl ammatory Cytokines and Expression of Perilipin 2 in Lipopolysaccharide-Stimulated Microglia in Part via Inhibition of NF-κB and AP-1 Activation. PLoS One.2015：10（9）e0137837.（IF：3.234）
8.Liu H，Le W（通讯作者）．Center for Translational Research on Neurological Disease，1st Af fi liated Hospital of Dalian Medical University.Chronic hypoxia facilitates Alzheimer’s disease through demethylation of γ-secretase by downregulating DNA methyltransferase 3b. Alzheimers Dement.2015；［Epub ahead of print］.（IF：12.407）
9.Tang Y，Le W（通讯作者）．Center for Translational Research on Neurological Disease，1st Af fi liated Hospital of Dalian Medical University.Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases .Mol Neurobiol.2015；［Epub ahead of print］.（IF：5.137）
10.Li T，Le W（通讯作者）．Center for Translational Research on Neurological Disease，1st Af fi liated Hospital of Dalian Medical University.Critical role of Tet3 in neural progenitor cell maintenance and terminal differentiation. Mol Neurobiol.2015；51（1）：142-54.（IF：5.137）
11.Le W（通讯作者），John D（通讯作者）．Center for Translational Research on Neurological Disease，1st Af fi liated Hospital of Dalian Medical University.Pitx3 de fi ciency produces decreased dopamine signaling and induces motor de fi cits in Pitx3（-/-）mice .Neurobiology of Aging.2015；［In press］.（IF：5.013）
12.Liu H，Le W（通讯作者）．Center for Translational Research on Neurological Disease，1st Af fi liated Hospital of Dalian Medical University.Chronic Hypoxia-Induced Autophagy Aggravates the Neuropathology of Alzheimer’s Disease through AMPK-mTOR Signaling in the APPSwe/PS1dE9 Mouse Model .Journal of Alzheimers Disease.2015；48（4）：1019-1032.（IF：4.151）
13.Chen S，Le W（通讯作者）．Center for Translational Research on Neurological Disease，1st Af fi liated Hospital of Dalian Medical University.A New VMAT-2 Inhibitor NBI-641449 in the Treatment of Huntington Disease. CNS Neurosci Ther.2015；21（8）：662-71.（IF：3.931）
14.Zhang S，Le W（通讯作者）．Center for Translational Research on Neurological Disease，1st Af fi liated Hospital of Dalian Medical University.Olfactory dysfunction and neurotransmitter disturbance in olfactory bulb of transgenic mice expressing human A53T mutant α-synuclein. PLoS One.2015；10（3）：e0119928.（IF：3.234）
宁夏回族自治区
1.杨晓军，王振海（通讯作者）．宁夏医科大学总医院．High-throughput sequencing of 16S rDNA amplicons characterizes bacterial composition in bronchoalveolar lavage fluid in patients with ventilator-associated pneumonia. Dove Press journal： Drug Design， Development and Therapy.2015；9：4883-4896.（IF：3.02）
2.刘爱翠，王振海（通讯作者）．宁夏医科大学总医院．High-throughput sequencing of 16S rDNA amplicons characterizes bacterial composition in cerebrospinal fl uid samples from patients with purulent meningitis. Dove Press journal： Drug Design， Development and Therapy.2015（9），4417-4429.（IF：3.02）
3.李海宁．宁夏医科大学总医院．Oxymatrine attenuated hypoxic-ischemic brain damage in neonatal rats via improving antioxidant enzyme activities and inhibiting cell death. NEUROCHEMISTRY INTERNATIONAL.2015（89），17-27.（IF：3.092）
4.杨平．宁夏医科大学总医院．Genetic Association of CUGBP2 and DNMBP with Alzheimer’s Disease in the Chinese Han Population .CURRENT ALZHEIMER RESEARCH.2015（12），3，228-232.（IF：3.889）
5.杨笑．宁夏医科大学总医院．Inhibition of mTOR Pathway by Rapamycin Reduces Brain Damage in Rats Subjected to Transient Forebrain Ischemia. International Journal of Biological Sciences.2015；11（12）：1424-1435.（IF：4.509）
青海省
1.吴世政．青海省人民医院．Increasing Bcl-2 and Neuroglubin Expression in Hypoxic Hippocampal Neurons under Hypoxia Preconditioning and in 3-n-butylphalide Treated Cells under Oxygen Glucose Deprivation/Reoxygenation Clinical Immunology .Endocrine & Metabolic Drugs， Bentham Science Publishers 2015，2，000-000.（IF：3.992）
2.吴世政．青海省人民医院．Cerebral Vasoconstrintion reactions and plasma lebels of ETBR ET-1 eNOS in patients with chronic mountain sickness. Molecular Medicine Reports.（IF：1.554）
3.朱爱琴．青海省人民医院．The Neuroprotective Effects of Ratanasampil on Oxidative Stress-Mediated Neuronal Damage in Human Neuronal SH-SY5Y Cells. Oxidative Medicine and Cellular Longevity.2015May3 doi：101155/2015/792342.（IF：3.52）
山西省
1.蔚洪恩．山西省人民医院．Proteomic analysis of cortical brain tissue from the BTBR mouse model of autism：evidence for changes in STOP and myelin-related proteins. Neuroscience.2016：312.（IF：3.357）
2.J ZHANG（张金），X-Y NIU（牛小媛）．Department of Neurology，First Hospital of Shanxi Medical University.HYPERHOMOCYSTEINEMIA IS ASSOCIATED WITH VITAMIN B-12 DEFICIENCY：A CROSSSECTIONAL STUDY IN A RURAL，ELDERLY POPULATION OF SHANXI CHINA .J Nutr Health Aging.2015（电子版）．（IF：3.02）
3.Sun Hong，Wu HaiQing.Second Af fi liated Hosptal，Medical School of Xi’an Jiaotong University.Angiotension II and its receptor in activated microglia enhanced neuronal loss and cognitive impairment following pilocarpineinduced status epilepticu. Molecular and Cellular Neuroscienc.2015；65：58-67.（IF：3.89）
4.Sun Hong.Second Affiliated Hosptal，Medical School of Xi’an Jiaotong University.The PPARγagonist rosiglitazone prevents neuronal loss and attenuates development of spontaneous recurrent seizures through BDNF/TrkB signaling following pilocarpine-induced status epilepticus. Neurochem int.2013；65（5）：405-412.（IF：3.01）
5.Bu Ning.Department of Neurology，The Second Affiliated Hosptal，Medical School of Xi’an Jiaotong University.Exosome-loaded dendritic cells elicit；tumor-speci fi c CD8+ cytotoxic T cells in patients with glioma.Journal of Neuro-oncology.2011 Sep；104（3）：659-67.（IF：3.07）
四川省
1.曹蓓，商慧芳．四川大学华西医院．The Global Cognition，Frontal Lobe Dysfunction and Behavior Changes in Chinese Patients With Multiple System Atrophy. PLoS One. 2015；10（10）：e0139773.（IF：3.235）
2.杨兴龙，徐严明．四川大学华西医院．Association of Histamine N-Methyltransferase Thr105ile Polymorphism With Parkinson’s Disease and Schizophrenia in Han Chinese：a Case-Control Study. PLoS One. 2015 Mar 13；10（3）：e0119692.（IF：3.236）
3.杨兴龙，徐严明．四川大学华西医院．Association of the Coq2 V393a Variant With Parkinson’s Disease：a Case-Control Study and Meta-Analysis. PLoS One. 2015 Jun 22；10（6）：e0130970.（IF：3.237）
4.陈永平，商慧芳．四川大学华西医院．Genetic Variants of Snca Are Associated With Susceptibility to Parkinson’s Disease but Not Amyotrophic Lateral Sclerosis or Multiple System Atrophy in a Chinese Population. PLoS One. 2015 Jul 24；10（7）：e0133776.（IF：3.238）
山东省
1.Liu LB，Xu AD（通讯作者）．THE FIRST AFFILIATED HOSPITAL OF JINAN UNIVERDITY.The role of hs-CRP，D-dimer and fi brinogen in differentiating etiological subtypes of ischemic Stroke.PLoS One.2015；10（2）：e0118301.（IF：3.234）
2.Dan L，Daxiang Lu（通讯作者）．THE FIRST AFFILIATED HOSPITAL OF JINAN UNIVERDITY.The synergistic effects of heat shock protein 70 and ginsenoside Rg1 against tert-butyl hydroperoxide damage model in vitro .Oxid Med Cell Longev.2015；437127.（IF：3.516）
3.Yang Z，Xu A（通讯作者）．THE FIRST AFFILIATED HOSPITAL OF JINAN UNIVERDITY.Bone marrow stromal cell transplantation through tail vein injection promotes angiogenesis and vascular endothelial growth factor expression in cerebral infarct area in rats. Cytotherapy.2015；17（9）：1200-12.（IF：3.293）
4.Heng Meng，Wei-Ping Liao（通讯作者）．THE FIRST AFFILIATED HOSPITAL OF JINAN UNIVERDITY.The SCN1A mutation database：updating information and analysis of the relationships among genotype，functional alteration，and phenotype .Human mutation. 2015 36（6）：573-580.（IF：5.34）
5.Zhen Jing，Li’an Huang（通讯作者）．THE FIRST AFFILIATED HOSPITAL OF JINAN UNIVERDITY.Chronic cerebral hypoperfusion induces vascular plasticity and hemodynamics but also neuronal degeneration and cognitive impairment. Journal of Cerebral Blood Flow & Metabolism.（2015）35，1249-1259.（IF：5.4）
6.Lili Cui，Keshen Li（共同通讯作者），Bin Zhao（通讯作者）．JINAN UNIVERDITY.A Novel，Multi-Target Natural Drug Candidate，Matrine，Improves Cognitive Deficits in Alzheimer’s Disease Transgenic Mice by Inhibiting AβAggregation and Blocking the RAGE/Aβ Axis. Molecular Neurobiology. 2016 Feb 22 ［Epub ahead of print］.（IF：5.137）
7.Keshen Li，Guiyou Liu.THE FIRST AFFILIATED HOSPITAL OF JINAN UNIVERDITY.REST rs3796529 variant does not confer susceptibility to Alzheimer’s disease .Annals of Neurology.2015 Nov；78（5）：835-836 doi：101002/ana24503.（IF：9.977）
上海市
1.Z Xu，Sheng-Di Chen（通讯作者），J Feng（通讯作者）．上海交通大学医学院附属瑞金医院神经内科．Direct conversion of human fibroblasts to induced serotonergic neurons .Mol Psychiatry.2015 28-Jul article.（IF：14.496）
2.李雯，Sheng-Di Chen（通讯作者），Jia-Yi Li（通讯作者）．上海交通大学医学院附属瑞金医院神经内科．Human induced pluripotent stem cells in Parkinson’s disease：A novel cell source of cell therapy and disease modeling .Prog Neurobiol.2015；134：161-177 review.（IF：9.992）
3.Jun-Ling Wang#（第一作者），唐北沙（通讯作者），曹立（通讯作者），陈生弟（通讯作者）．上海交通大学医学院附属瑞金医院神经内科．Paroxysmal kinesigenic dyskinesia Clinical and genetic analyses of 110 patients. Neurology.2015；85（18）：1546-53 article.（IF：8.286）
4.汪洋，杨国源（通讯作者）．上海交通大学医学院附属瑞金医院神经内科．MicroRNA-29b is a therapeutic target in cerebral ischemia associated with aquaporin 4 . J Cereb Blood Flow Metab.2015；35（12）：1977-84 article.（IF：5.407）
5.Yong-Fang Zhang#（第一作者），陈生弟（通讯作者），王刚（通讯作者），程琪（通讯作者）．上海交通大学医学院附属瑞金医院神经内科．Peripheral blood microRNA expression profiles in Alzheimer’s disease：screening，validation，association with clinical phenotype and implications for molecular mechanism. Mol Neurobiol.2015，Oct 26 article.（IF：5.137）
6.蒋天放，陈生弟（通讯作者），张京（通讯作者）．上海交通大学医学院附属瑞金医院神经内科．P2X7 receptor is critical in α-synuclein—mediated microglial NADPH oxidase activation .Neurobiol Aging.2015；36（7）：2304-2318 article.（IF：5.013）
7.王瑛，jian Zhao（通讯作者），丁健青（通讯作者）．上海交通大学医学院附属瑞金医院神经内科．The combination of aricept with a traditional chinese medicine formula，smart soup，may be a novel way to treat alzheimer’s disease. J Alzheimers Dis.2015；45（4）：1185-95 article.（IF：4.151）
8.汤荟冬，马建芳（通讯作者），陈生弟（通讯作者）．上海交通大学医学院附属瑞金医院神经内科．Prevalence and risk factor of cognitive impairment were different between urban and rural population：a community-based study .J Alzheimers Dis.2015 Oct 27；49（4）：917-25 article.（IF：4.151）
9.Wang G，Chen SD（通讯作者），Huang Y（通讯作者）．上海交通大学医学院附属瑞金医院神经内科．Variants in the SNCA gene associate with motor progression while variants in the MAPT gene associate with the severity of Parkinson’s disease. Parkinsonism & Related Disorders. Epub2015Dec30.（IF：3.972）
10.陈晟，乐卫东（通讯作者）．上海交通大学医学院附属瑞金医院神经内科．A New VMAT-2 Inhibitor NBI-641449 in the Treatment of Huntington Disease. CNS Neurosci Ther.2015；21（8）：662-71.（IF：3.9）
11.李敦辉，张琳源（第一作者）刘军（通讯作者），陈生弟（通讯作者）．上海交通大学医学院附属瑞金医院神经内科．Transcranial sonography of the substantia nigra and its correlation with DAT-SPECT in the diagnosis of Parkinson’s disease. Parkinsonism and Related Disorders.2015；21：923-928.（IF：3.9）
12.陈伟，康文岩（第一作者）刘军（通讯作者），陈生弟（通讯作者）．上海交通大学医学院附属瑞金医院神经内科．Hyposmia correlates with SNCA variant and non-motor symptoms in Chinese patients with Parkinson’s disease .Parkinsonism and Related Disorders.2015；21（6）：610-614 article.（IF：3.9）
13.王晰（第一作者）陈生弟（通讯作者）．上海交通大学医学院附属瑞金医院神经内科．Prevalence and clinical features of non-motor symptoms of essential tremor in Shanghai rural area. Parkinsonism and Related Disorders.2015 Nov 4.（IF：3.9）
14.方嵘，陈生弟（通讯作者）．上海交通大学医学院附属瑞金医院神经内科．Disrupted Structural Brain Network in AD and aMCI：A Finding of Long Fiber Degeneration. Curr Alzheimer Res.2015；12（6）：572-584.（IF：3.889）
15.李彬寅 陈生弟（通讯作者）．上海交通大学医学院附属瑞金医院神经内科．Mental training for cognitive improvement in elderly people：What have we learned from clinical and neurophysiologic studies .Curr Alzheimer Res.2015；12（6）：543-552 review.（IF：3.889）
16.Xu J，Chen SD（通讯作者），Wang G（通讯作者）．上海交通大学医学院附属瑞金医院神经内科．Testosterone，estradiol，and sex hormone-binding globulin in Alzheimer’s disease：a meta-analysis .Curr Alzheimer Res.2016；13（3）：215-22 review.（IF：3.889）
17.李敦辉，刘军（通讯作者）．上海交通大学医学院附属瑞金医院神经内科．Serum insulin-like growth factor-1 in patients with de novo，drug naïve Parkinson’s disease：a meta-analysis. PLoS One.2015；10（12）：e0144755 article.（IF：3.8）
18.马建芳 陈生弟（通讯作者）．上海交通大学医学院附属瑞金医院神经内科．Plasma insulin-like growth factor 1 is associated with cognitive impairment in parkinson’s disease. Dement geriatr Cogn disord.2015；93：251-256 article.（IF：3.5）
19.潘静，李卉（第一作者），陈生弟（通讯作者）．上海交通大学医学院附属瑞金医院神经内科．Small peptide inhibitor of JNK3 protects dopaminergic neurons from MPTP induced injury via inhibiting the ASK1-JNK3 signaling pathway. PLOS ONE.2015；9：420-22 article.（IF：3.234）
20.周夷，陈生弟（通讯作者），汤荟冬（通讯作者）．上海交通大学医学院附属瑞金医院神经内科．Clinical characteristics for the relationship between Type-2 diabetes mellitus and cognitive impairment：a cross-sectional study .Aging Dis.2015；6（4）：236-244 article.（IF：3.07）
21.孙倩，刘军（通讯作者），陈生弟（通讯作者）．上海交通大学医学院附属瑞金医院神经内科．Effect of a leucine-rich repeat kinase 2 variant on motor and non-motor symptoms in chinese Parkinson’s disease patients. Aging and Disease.2015 http://dxdoiorg/1014336/AD20151026article.（IF：3.07）
22.蒋倩雯，马建芳（通讯作者），陈生弟（通讯作者）．上海交通大学医学院附属瑞金医院神经内科．Plasma epidermal growth factor decreased in the early stage of parkinson’s disease. Aging and Disease.2015；6（3）：168-173 article.（IF：3.0）
23.Wang XJ，Liu Z.上海交通大学医学院附属新华医院神经内科．Aging-related rotenone-induced neurochemical and behavioral de fi cits：role of SIRT2 and redox imbalance，and neuroprotection by AK-7. Drug Design， Development and Therapy.2015；9：2553-2563.（IF：3.028）
24.Gan J，Liu Z.上海交通大学医学院附属新华医院神经内科．Roles of Ca 2+/calmodulin-dependent protein kinase IIin subcellular expression of striatal N-Methyl-D-aspartate receptors in l-3，4-dihydroxyphenylalanineinduced dyskinetic rats. Drug Design， Development and Therapy.2015；9：2119-2128.（IF：3.028）
25.Xie CL，Liu ZA.上海交通大学医学院附属新华医院神经内科．systematic review and meta-analysis of Ginsenoside-Rg1（G-Rg1）in experimental ischemic Stroke .Scienti fi c Reports.，2015，20；5：7790.（IF：5.078）
天津市
1.Zhu Z，Shi FD（通讯作者）．天津医科大学总医院．Combination of an immune modulator fingolimod with alteplase in acute ischemic Stroke.Circulation.V 2015，22；132（12）：1104-12.（IF：15.457）
2.Fu Y，Shi FD（通讯作者）．天津医科大学总医院．Immune interventions in Stroke.Nat Rev Neurol.2015，11（9）：524-35.（IF：15.38）
3.Liu Y，Fu Y（共同通讯）．天津医科大学总医院．Structural MRI substrates of cognitive impairment in neuromyelitis optica .Neurology.2015 Oct 27；85（17）：1491-9.（IF：9.674）
4.Pan J，Fu Y（通讯作者）．天津医科大学总医院．Hypoxemia，Sleep Disturbances，and Depression Correlated with Fatigue in Neuromyelitis Optica Spectrum Disorder .CNS Neurosci Ther.2015，21（7）：599-606.（IF：3.931）
5.Jin WN，Xu Y（通讯作者），Liu Q（通讯作者）．天津医科大学总医院．Non-invasive tracking of CD4+ T cells with a paramagnetic and fl uorescent nanoparticle in brain ischemia .J Cereb Blood Flow Metab.2015 Oct 19.（IF：5.407）
6.Liu Q（第一，共同通讯）Wu J.天津医科大学总医院．A novel nicotinic mechanism underliesβ-amyloidinduced neurotoxicity. Neuropharmacology.2015 Oct；97：457-63.（IF：5.106）
7.Liu Q（通讯作者），Wu J.天津医科大学总医院．Roles of nAChR subunit cytoplasmic loops in acute desensitization. Neuroscience.2015 Mar 19；289：315-23.（IF：3.357）
8.Liu Y，Li K.天津医科大学总医院．Whole brain functional connectivity in clinically isolated syndrome without conventional brain MRI lesions .Eur Radiol.2015 Dec 29 ［Epub ahead of print］.（IF：4.014）
9.Liu Y，Li K.天津医科大学总医院．Multimodal Quantitative MR Imaging of the Thalamus in Multiple Sclerosis and Neuromyelitis Optica .Radiology.2015 Dec；277（3）：784-9.（IF：6.867）
10.Liu Y，Barkhof F.天津医科大学总医院．DIF：ferential patterns of spinal cord and brain atrophy in NMO and MS .Neurology.2015 Apr 7；84（14）：1465-72.（IF：8.286）
11.Chen L，Hao J（通讯作者）．天津医科大学总医院．T cell immunity to glatiramer acetate ameliorates cognitive de fi cits induced by chronic cerebral hypoperfusion by modulating the microenvironment .Sci Rep.2015 Sep 22；5：14308.（IF：5.578）
12.Wei C，Hao J（通讯作者）．天津医科大学总医院．Factors associated with post-stroke depression and fatigue：lesion location and coping styles. J Neurol.2016 Feb；263（2）：269-76.（IF：3.377）
13.Yan T，Chen J（通讯作者）．天津医科大学总医院．Neurorestorative Therapy of Stroke in Type 2 Diabetes Mellitus Rats Treated With Human Umbilical Cord Blood Cells .Stroke.2015 Sep；46（9）：2599-606.（IF：5.723）
14.Luo L，Yan T（通讯作者）1.天津医科大学总医院．Cortisol Supplement Combined with Psychotherapy and Citalopram Improves Depression Outcomes in Patients with Hypocortisolism after Traumatic Brain Injury .Aging Dis.2015 Nov 17；6（6）：418-25.（IF：3.07）
15.Zhang LJ，Yang L（通讯作者）．天津医科大学总医院．Olfactory dysfunction in neuromyelitis optica spectrum disorders. J Neurol.2015 Aug；262（8）：1890-8.（IF：3.377）
16.Zhang N，Cheng Y.天津医科大学总医院．The Effect of Memantine on Cognitive Function and Behavioral and Psychological Symptoms in Mild-to-Moderate Alzheimer’s Disease Patients. Dement Geriatr Cogn Disord.2015；40（1-2）：85-93.（IF：3.547）
17.Zhang N，Liu Y.天津医科大学总医院．Cognitive impairment in Chinese neuromyelitis optica. Mult Scler.2015 Dec；21（14）：1839-46.（IF：4.844）
18.Zhang N，Cheng Y.天津医科大学总医院．Repetitive transcranial magnetic stimulation enhances spatial learning and synaptic plasticity via the VEGF and BDNF-NMDAR pathways in a rat model of vascular dementia. Neuroscience.2015 Dec 17；311：284-91.（IF：3.357）
浙江省
1.苏杭/何金彩．温州医科大学附属第一医院．The Effects of BDNF Val66Met Gene Polymorphism on Serum BDNF and Cognitive Function in Methamphetamine-Dependent Patients and Normal Controls：A Case-Control Study .J Clin Psychopharmacol.2015 Oct；35（5）：517-243.（IF：3.243）
2.朱琳/何金彩．温州医科大学附属第一医院．The association between serum ferritin levels and post-stroke depression .journal of affective disorders.2015 Oct 14；190：98-102.（IF：3.383）
3.谷赢赢/何金彩．温州医科大学附属第一医院．Low serum levels of uric acid are associated with development of post-stroke depression. Medicine（ Baltimore）．2015 Nov；94（45）：e1897.（IF：5.723）
4.岺志东，罗巍（通讯作者）．Zhejiang Univ，Af fi liated Hosp 2，Sch Med，Dept Neurol.Fine mapping and wholeexome sequencing of a familial cortical myoclonic tremor with epilepsy family. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS.2015；7：595-599.（IF：3.416）
5.卢海鹏，吴志英（通讯作者）．Zhejiang Univ，Affiliated Hosp 2，Sch Med，Dept Neurol.Intermediate-length polyglutamine in ATXN2 is a possible risk factor among Eastern Chinese patients with amyotrophic lateral sclerosis.NEUROBIOLOGY OF AGING.2015；3：1603.（IF：5.013）
6.干诗瑞，吴志英（通讯作者）．Zhejiang Univ，Affiliated Hosp 2，Sch Med，Dept Neurol.Population Genetics and New Insight into Range of CAG Repeats of Spinocerebellar Ataxia Type 3 in the Han Chinese Population. PLOS ONE.2015；8：e0134405.（IF：3.234）
7.林岳韩，楼敏（通讯作者）．Zhejiang Univ，Affiliated Hosp 2，Sch Med，Dept Neurol.Docosahexaenoic acid attenuates hyperglycemia-enhanced hemorrhagic transformation after transient focal cerebral ischemia in rats. NEUROSCIENCE.2015；301：471-479.（IF：3.357）
8.雷小光，张宝荣（通讯作者）．Zhejiang Univ，Affiliated Hosp 2，Sch Med，Dept Neurol.1-Methyl-4-Phenylpyridinium Stereotactic Infusion Completely and SpecIF：ically Ablated the Nigrostriatal Dopaminergic Pathway in Rhesus Macaque. PLOS ONE.2015；10：e0127953.（IF：3.234）
9.童璐莎，楼敏（通讯作者）．Zhejiang Univ，Affiliated Hosp 2，Sch Med，Dept Neurol.Statin Withdrawal Beyond Acute Phase Affected Outcome of Thrombolytic Stroke Patients An Observational Retrospective Study .MEDICINE.2015；94：e779.（IF：5.723）
10.杨平，吴志英（通讯作者）．Zhejiang Univ，Af fi liated Hosp 2，Sch Med，Dept Neurol.Genetic Association of CUGBP2 and DNMBP with Alzheimer’s Disease in the Chinese Han Population. CURRENT ALZHEIMER RESEARCH.2015；12：228-232.（IF：3.889）
11.雷小光，张宝荣（通讯作者）．Zhejiang Univ，Affiliated Hosp 2，Sch Med，Dept Neurol.Drift in centrality of different brain regions in an anatomical neural network with parkinson’s disease：a view from complex network analysis. NEUROSCIENCE.2015；299：107-124.（IF：3.357）
12.国杨，楼敏（通讯作者）．Zhejiang Univ，Affiliated Hosp 2，Sch Med，Dept Neurol.Lower Serum Calcium Level Is Associated With Hemorrhagic Transformation After Thrombolysis. STROKE.2015；46：1359-1361.（IF：5.723）
13.谢飞，罗巍（通讯作者）．Zhejiang Univ，Affiliated Hosp 2，Sch Med，Dept Neurol.Homozygous pD331Y mutation in PLA2G6 in two patients with pure autosomal-recessive early-onset parkinsonism：Further evidence of a fourth phenotype of PLA2G6-associated neurodegeneration. PARKINSONISM & RELATED DISORDERS.2015；21：420-422.（IF：3.972）
14.张圣，楼敏（通讯作者）．Zhejiang Univ，Affiliated Hosp 2，Sch Med，Dept Neurol.Optimal Magnetic Resonance Perfusion Thresholds Identifying Ischemic Penumbra and Infarct Core：A Chinese Populationbased Study. CNS NEUROSCIENCE & THERAPEUTICS.2015；21：289-295.（IF：3.931）
15.严慎强，楼敏（通讯作者）．Zhejiang Univ，Affiliated Hosp 2，Sch Med，Dept Neurol.Extensive cerebral microbleeds predict parenchymal haemorrhage and poor outcome after intravenous thrombolysis. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY.2015；86：1267-1272.（IF：6.807）
16.陈艳杏，龚成新（通讯作者）．Zhejiang Univ，Affiliated Hosp 2，Sch Med，Dept Neurol.Targeting Insulin Signaling for the Treatment of Alzheimer’s Disease .CURRENT TOPICS IN MEDICINAL CHEMISTRY.2015；16：485-492.（IF：3.402）
17.娄毓婷，罗巍（通讯作者）．Zhejiang Univ，Affiliated Hosp 2，Sch Med，Dept Neurol.Altered brain network centrality in depressed Parkinson’s disease patients. MOVEMENT DISORDER.2015；30：1777 -1784.（IF：5.68）
18.祝一宏，汤业磊（通讯作者）．Zhejiang Univ，Af fi liated Hosp 2，Sch Med，Dept Neurol.Intrinsic Brain Activity as a Diagnostic Biomarker in Children With Benign Epilepsy With Centrotemporal Spikes. HUMAN BRAIN MAPPING.2015；36：3878-3889.（IF：5.969）
19.浦佳丽，冯简（通讯作者）．Zhejiang Univ，Af fi liated Hosp 2，Sch Med，Dept Neurol.Generation of Naivetropic Induced Pluripotent Stem Cells from Parkinson’s Disease Patients for High-Ef fi ciency Genetic Manipulation and Disease Modeling. STEM CELLS DEV.2015；24：2591-2604.（IF：4.459）
20.夏萍，楼敏（通讯作者）．Zhejiang Univ，Affiliated Hosp 2，Sch Med，Dept Neurol.Risk factors for subdural haematoma in patients with spontaneous intracranial hypotension. PLOS ONE.2015；10：e0123616.（IF：3.234）
21.文晓丹，李宏福（共同一作），吴志英（通讯作者）．Zhejiang Univ，Af fi liated Hosp 2，Sch Med，Dept Neurol.Mutation Analysis of COQ2 in Chinese Patients with Cerebellar Subtype of Multiple System Atrophy. CNS NEUROSCI THER.2015；21：626-630.（IF：3.931）
22.朱敏，吴志英（通讯作者）．Zhejiang Univ，Affiliated Hosp 2，Sch Med，Dept Neurol. Defective roles of ATP7B missense mutations in cellular copper tolerance and copper excretion. Mol Cell Neurosci.2015；67：31-36.（IF：3.84）
23.Peng GP，Luo BY.zhejiang Univ，Affiliated Hosp 1，Sch Med，Dept Neurol.Correlation of Hippocampal Volume and Cognitive Performances in Patients with Either Mild Cognitive Impairment or Alzheimer’s disease. CNS Neurosci Ther.2015；21（1）：15-22.（IF：3.931）
24.Chen Z，Luo B.zhejiang Univ，Af fi liated Hosp 2，Sch Med，Dept Neurol.Is Radical-by-Radical reading strategy effective for Chinese Pure Alexia A case study. Neuropsychology.2015；29（3）：402-8.（IF：3.269）
25.Wei R，Xu Y（通讯作者）．zhejiang Univ，Affiliated Hosp 3，Sch Med，Dept Neurol.Probenecid protects against cerebral ischemia/reperfusion injury by inhibiting lysosomal and inflammatory damage in rats. Neuroscience.2015；301：168-77.（IF：3.357）
26.Liu X，Zhang Z.zhejiang Univ，Af fi liated Hosp 4，Sch Med，Dept Neurol.The association between TOMM40 gene polymorphism and spontaneous brain activity in amnestic mild cognitive impairment. J Neurol.2015；261（8）：1499-507.（IF：6.344）
27.Liang H，Yue W.zhejiang Univ，Af fi liated Hosp 5，Sch Med，Dept Neurol.Reversible cerebral vasoconstriction syndrome following red blood cells transfusion：a case series of 7 patients. Orphanet J Rare Dis.2015；10：47.（IF：3.358）
28.张雄，祝建洪（通讯作者）．温州医科大学．Aldehyde dehydrogenase 2 genetic variations may increase susceptibility to Parkinson’s disease in Han Chinese population. Neurobiology of Aging.2015 Sep；36（9）：2660e9-13.（IF：5.013）
29.王建勇，祝建洪（通讯作者）．温州医科大学．The RIT2 and STX1B polymorphisms are associated with Parkinson’s disease. Parkinsonism & Related Disorders.2015 Mar；21（3）：300-2.（IF：3.972）
30.李岩，陈江帆（通讯作者）．温州医科大学．Optogenetic Activation of Adenosine A2A Receptor Signaling in the Dorsomedial Striatopallidal Neurons Suppresses Goal-Directed. Neuropsychopharmacology.2015 Jul 28 doi：101038/npp2015227.（IF：7.048）
31.陈江帆（通讯作者）．温州医科大学．Adenosine A2A Receptors Mediate Anti-Inflammatory Effects of Electroacupuncture on Synovitis in Mice with Collagen-Induced Arthritis .Evidence-Based Complementary and Alternative Medicine.2015；2015：809560 doi：101155/2015/809560.（IF：4.774）
32.郑国庆（通讯作者）．温州医科大学．Active Compounds of Rhubarb Root and Rhizome in Animal Model Experiments of Focal Cerebral Ischemia.Evidence-Based Complementary and Alternative Medicine.2015：210546.（IF：4.774）
33.郑国庆（通讯作者）．温州医科大学．Neuroprotection of Sanhua Decoction against Focal Cerebral Ischemia/Reperfusion Injury in Rats through a Mechanism Targeting Aquaporin. Evidence-Based Complementary and Alternative Medicine.2015：584245.（IF：4.774）
六、其他
（一）专利：
1.一种压力刺激试验装置、系统，专利号：ZL 2014 2 0736951.0，证书号：第4273114号，发明人：于生元，谢敬聃，白逸冰，王志强，刘若卓，董钊；专利权人：于生元，谢敬聃。
2.便携式感觉功能检查仪，专利号：ZL 2014 2 0713244.X，证书号：第4273225号，发明人：于生元，谢敬聃，唐飞，王志强，刘若卓，刘华；专利权人：于生元，谢敬聃。
3.温度刺激试验机，专利号：CN104434036A。发明人：于生元，谢敬聃，唐飞，王志强，张威，唐闻晶；专利权人：于生元，谢敬聃。
4.温度刺激试验机，专利号：CN204293136U。发明人：于生元，谢敬聃，唐飞，王志强，张威，唐闻晶；专利权人：于生元，谢敬聃。
5.一种清醒状态下偏头痛动物模型造模仪，专利号：CN104623803A。发明人：于生元，王晓琳，董钊，刘若卓。
6.X26/CTX-PL/pC27复合物及其在治疗神经胶质瘤中的应用。中国专利号：ZL201310335451.6 授权日期：2015年8月 发明人：彭 英，岳陪建，何蕾。
7.刘保茹．河南科技大学第一附属医院．一种用于密闭腰椎穿刺及脑脊液置换的装置，实用新型专利，专利号：ZL 2015 2 0229794.9。
（二）专著：
1.董为伟．神经系统与全身性疾病［M］.北京：科学出版社，2015.
2.乐卫东．自噬-生物学与疾病（临床卷）［M］.2版．北京：科学出版社，2015.
3.王佃亮，乐卫东．生物药物与临床应用［M］.北京：人民军医出版社，2015.
4.程丽妞．临床神经内科疾病诊治［M］.长春：吉林科学技术出版社，2015.
5.武晓玲．神经系统介入治疗与康复学［M］.长春：吉林科学技术出版社，2015.